Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Yanyan ZhuDaidi Fan

Abstract

Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, but the effect of Rg5 on DN and its potential mechanism remains unclear. The aim of this study is to investigate the effect of Rg5 on kidney injury of C57BL/6 diabetic mice induced by high-fat diet and streptozotocin. After treatment with different concentration of Rg5 (30 and 60 mg kg-1·d-1) for 6 consecutive weeks, the fasting blood glucose, insulin levels, serum creatinine, serum urea, and serum UA in Rg5-treated DN mice were significantly reduced, while the renal histopathology was remarkably improved, compared with untreated DN mice. Moreover, ROS production, oxidative stress markers (MDA, SOD, and GSH-PX), Nox4 and TXNIP expressions of kidney in DN mice were significantly reduced after Rg5 treatment. Additionally, the expression levels of the NLRP3 inflammasome (NLRP3, ASC, and Caspase-1) and the inflammatory cytokines IL-1β and IL-18 were significantly inhibited, and the expression of NF-kB and the phosphoryla...Continue Reading

Citations

Jul 12, 2020·International Journal of Molecular Sciences·Beatriz Castejón-VegaJosé M Alvarez-Suarez
Feb 12, 2021·International Journal of Molecular Sciences·Alison DominguesValérie Nivet-Antoine
Feb 10, 2021·Antioxidants & Redox Signaling·Santiago Cuevas, Pablo Pelegrín
Apr 10, 2021·The Journal of Pharmacy and Pharmacology·Jing XuHang Song
May 22, 2021·Life Sciences·Seyed Hossein ShahcheraghiMurtaza M Tambuwala
Jun 22, 2021·Experimental and Therapeutic Medicine·Ming-Yang LiuHai-Jun Li
Aug 21, 2021·Journal of Agricultural and Food Chemistry·Linlin QuDaidi Fan
Sep 17, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Abdullah Al MamunJian Xiao

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