Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats

European Journal of Pharmacology
Tzu-Yu LinShu Kuei Huang

Abstract

Hispidulin is a flavonoid compound which is an active ingredient in a number of traditional Chinese medicinal herbs, and it has been reported to inhibit glutamate release. The purpose of this study was to investigate whether hispidulin protects against seizures induced by kainic acid, a glutamate analog with excitotoxic properties. The results indicated that intraperitoneally administering hispidulin (10 or 50mg/kg) to rats 30 min before intraperitoneally injecting kainic acid (15 mg/kg) increased seizure latency and decreased seizure score. In addition, hispidulin substantially attenuated kainic acid-induced hippocampal neuronal cell death, and this protective effect was accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus. Moreover, hispidulin reduced kainic acid-induced c-Fos expression and the activation of mitogen-activated protein kinases in the hippocampus. These data suggest that hispidulin has considerable antiepileptic, neuroprotective, and antiinflammatory effects on kainic acid-induced seizures in rats.

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Citations

Jan 22, 2017·Journal of Neuroinflammation·Ming-Tao YangWang-Tso Lee
Jan 20, 2018·International Journal of Molecular Sciences·Xinjia HanHuishu Liu
Jun 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Eun KimTaeg Kyu Kwon
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Nov 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Pei LiuXiaoyin Chen
Mar 13, 2021·Epilepsy & Behavior : E&B·Maria Kueirislene Amâncio FerreiraHélcio Silva Dos Santos
Dec 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lubin HuangHong Ning

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