Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Bioscience Reports
Jindong LiShengjun Ma

Abstract

In the present study, we aimed to investigate the effect of pulmonary arterial perfusion (PAP) with Histidine-tryptophan-ketoglutarate (HTK) on lung protection in infants with congenital heart disease (CHD) and pulmonary arterial hypertension (PAH) after cardiopulmonary bypass (CPB). Fifty infant patients with CHD and PAH at our hospital from January, 2016 to February, 2017 were randomly divided into control group and HTK group. The levels of interleukin-6 (IL-6), malondialdehyde (MDA), and endothelin-1 (ET-1) in serum were detected using ELISA Kit. Oxygen index (OI) and respiratory index (RI) were calculated at each time point. The time of postoperative mechanical ventilation and ICU stay was counted, and the right lower lung tissues in patients were taken for pathological examination. Compared with preanesthesia, the levels of IL-6, MDA, and ET-1 in the two groups were significantly increased after CPB, and their levels in HTK group were significantly lower than that in control group. Moreover, OI in control group decreased markedly and RI in control group increased significantly after CPB. Compared with control group, the postoperative mechanical ventilation time, postoperative ICU stay, and total hospital stay in HTK group ...Continue Reading

References

Mar 29, 2000·The Annals of Thoracic Surgery·T SuzukiI Kashima
Jun 14, 2002·The Journal of Thoracic and Cardiovascular Surgery·Christian SchlensakFriedhelm Beyersdorf
Jun 25, 2008·The Annals of Thoracic Surgery·Matthias SiepeChristian Schlensak
May 19, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Alejandro P Comellas, Arturo Briva
Jun 30, 2012·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Barbara DolińskaFlorian Ryszka

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
ELISA
MDA

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.