PMID: 8963945Jan 1, 1996Paper

Protective effect of human ulinastatin against gentamicin-induced acute renal failure in rats

Canadian Journal of Physiology and Pharmacology
M NakakukiM Mizota

Abstract

We investigated the protective effect of human ulinastatin against gentamicin-induced acute renal failure in rats. Gentamicin sulfate was subcutaneously injected at a dose of 200 mg/kg for 5 consecutive days. After 3 days administration of gentamicin, a slight decrease in renal function was observed, as well as granulovascular degeneration in the proximal tubular cells as a change in the renal histology. After 5 days administration of gentamicin, a remarkable increase in plasma concentration of creatinine (from 0.27 +/- 0.02 to 1.17 +/- 0.18 mg/dL) and urea nitrogen (from 17.8 +/- 0.6 to 48.8 +/- 5.1 mg/dL) and a significant decrease in creatinine clearance (from 0.64 +/- 0.08 to 0.20 +/- 0.03 mL.100 g-1.min-1) were observed. In addition, an apparent increase in urinary excretion of N-acetyl-beta-D-glucosaminidase and albumin was detected. In the renal histology, proximal tubular necrosis and desquamation of the epithelial cells in the cortex were observed. Furthermore, hyaline cast formation was frequently observed in the outer stripe of the outer medulla. Ulinastatin at doses of 100,000 or 300,000 U/kg was coadministered intraperitoneally just after each gentamicin injection. Ulinastatin treatment showed a dose-dependent supp...Continue Reading

Citations

Nov 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abdulhakeem A Al-MajedOthman A Al-Shabanah
Jan 18, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J Pugia, John A Lott
Apr 29, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ihsan Yaman, Engin Balikci
Mar 22, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaremi QuirósJosé M López-Novoa
Nov 16, 2016·Journal of Diabetes and Its Complications·Antonio Junior LepeddaMarilena Formato

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