Abstract
Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. We created three groups of K/BxN female mice that were positive for the anti-glucose-6-phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), anti-GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL-C, TCHO, and TG, decreased serum levels of HDL-C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL-C, TCHO, and TG, increased serum levels of HDL-C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups...Continue Reading
References
Oct 1, 1993·Seminars in Arthritis and Rheumatism·R I Fox
Jun 1, 1997·Annals of the Rheumatic Diseases·R MunroH A Capell
May 6, 1999·Immunity·A S KorganowD Mathis
Nov 27, 1999·Science·I MatsumotoD Mathis
Apr 17, 2002·The Journal of Experimental Medicine·Mariana MaccioniDiane Mathis
Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Aug 20, 2008·Nature Clinical Practice. Rheumatology·Peter C Taylor
Sep 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Malin E V JohanssonGunnar C Hansson
Dec 24, 2008·Annals of the Rheumatic Diseases·G Ruiz-IrastorzaM A Khamashta
Sep 24, 2009·Annals of the Rheumatic Diseases·M J L PetersM T Nurmohamed
Jan 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Richard KellermayerC Wayne Smith
Jun 28, 2012·Annals of the Rheumatic Diseases·Shawn RoseHarris Perlman
Apr 9, 2013·Nature Medicine·Robert A KoethStanley L Hazen
May 1, 2013·Infection and Immunity·J P GarciaF A Uzal
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Jun 28, 2013·Gut·Na-Ri ShinJin-Woo Bae
Oct 15, 2013·International Immunopharmacology·Cristen B ChafinChristopher M Reilly
Jan 29, 2014·Arthritis Care & Research·Daniel H SolomonElena Massarotti
Jun 20, 2014·Arthritis Research & Therapy·Lotta LjungLennart Jacobsson
Oct 12, 2014·Rheumatology·Churl Hyun ImYoung Mo Kang
Apr 19, 2015·Arthritis Research & Therapy·Ming ZongLieying Fan
Sep 29, 2015·PloS One·Ashutosh M ShuklaSudhir V Shah
Feb 19, 2016·Molecular Nutrition & Food Research·Chrysoula MatziouridouFrida Fåk
Mar 25, 2016·International Journal of Molecular Sciences·Xiaohao WuGe Zhang
May 5, 2016·Circulation·Jin LiAimin Xu
Nov 29, 2016·Nature Medicine·Hubert PlovierPatrice D Cani
Jan 11, 2017·Acta Scientiarum Polonorum. Technologia Alimentaria·Iwona Węgielska, Joanna Suliburska
Feb 6, 2017·Rheumatology·Aikaterini AridaPetros P Sfikakis
Mar 10, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Jose Felix RestrepoAgustin Escalante
Mar 18, 2017·Current Medicinal Chemistry·Changfeng HuChengping Wen
Apr 30, 2017·Seminars in Immunopathology·Kim Lauper, Cem Gabay
Oct 4, 2017·Annals of the Rheumatic Diseases·Claire RempenaultCharlotte Hua
Nov 11, 2017·Frontiers in Microbiology·Yue WangShengyong Mao
Dec 5, 2017·Atherosclerosis·Lin ZhuXizhong Shen
Mar 11, 2018·Atherosclerosis·Lora J KasselmanAllison B Reiss
Apr 20, 2018·Mediators of Inflammation·Alberto FlorisAlberto Cauli
Citations
Aug 28, 2020·Inflammation·Xiang Li, Yue Wang
Aug 3, 2019·Molecular Medicine·Yiyangzi MaHaitao Niu
Oct 7, 2020·Microorganisms·Carolina FerreiraFlávio Reis
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Stefano CelottoJacopo Demurtas
Feb 6, 2021·Nutrition·Bianca D BalmantDan L Waitzberg
Oct 30, 2020·Biomolecules·Oscar Zaragoza-GarcíaIris Paola Guzmán-Guzmán
Sep 14, 2021·Frontiers in Microbiology·Mei YangJiashun Chen
Nov 24, 2021·Gut Microbes·Clara DepommierPatrice D Cani