Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin.

Infection and Immunity
F A Klipstein, R F Engert

Abstract

The relative immunogenicities of three forms of the Escherichia coli heatlabile enterotoxin (LT), the holotoxin, its B subunit, and the polymyxin-release form (PM LT) were compared by immunizing rats with various dosages of each given exclusively by the parenteral (IP/IP) or peroral (PO/PO) routes or by a combination of the two (IP/PO). The degree of protection was evaluated by challenge in ligated ileal loops, and the serum antitoxin response was determined by an enzyme-linked immunosorbent assay with homologous antigens. When given by the PO/PO route, each LT antigen provided only weak protection against the toxin and virtually none against viable LT-producing strains; serum antitoxin titers were not significantly increased. When the toxins were given after a parental primary immunization by either the IP/IP or the IP/PO routes, each LT antigen provided a dose-related increase in serum antitoxin titers and in the degree of protection against the toxin as well as against viable strains which produce LT alone (LT(+)/ST(-)) or in combination with the heat-stable toxin (LT(+)/ST(+)). The degree of protection against viable bacteria, particularly the LT(+)/ST(+) strain, was stronger in animals which received booster immunizations ...Continue Reading

References

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Citations

Feb 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·I LönnrothS Lange
Jan 1, 1985·Pharmacology & Therapeutics·D C RobertsonF Dorner
Aug 1, 1984·Infection and Immunity·F A Klipstein, R F Engert
Nov 1, 1981·Infection and Immunity·F A KlipsteinJ D Clements
Jan 1, 1983·Infection and Immunity·F A KlipsteinR A Houghten

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