Abstract
The aim of the present study was to evaluate the effects of Lai Fu Cheng Qi decoction on myocardial injury in rats with severe acute pancreatitis (SAP). In total, 30 rats were randomly divided into sham, SAP and decoction treatment groups. SAP was induced by a retrograde pancreatic duct injection of 5% sodium taurocholate in the SAP and decoction treatment groups. Rats in decoction treatment group also received intragastric administration of Lai Fu Cheng Qi decoction. The serum levels of creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) were detected using an automatic biochemical analyzer. In addition, myocardial Na(+)-K(+)-ATPase activity was analyzed using a spectrophotometric method and the mitochondrial membrane potential was measured by flow cytometry. Myocardial apoptosis was assessed using a TUNEL assay and pathological changes to the heart and pancreas were detected by hematoxylin and eosin staining. Compared with the rats in the sham group, rats in the SAP and decoction treatment groups exhibited significantly higher levels of serum CK-MB and LDH, apoptosis index and pathological scores, and had significantly lower levels of Na(+)-K(+)-ATPase activity and mitochondrial membrane potential. However, when...Continue Reading
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Citations
Apr 8, 2020·World Journal of Gastroenterology : WJG·Lei LiHai-Long Chen
Jan 21, 2017·Experimental and Therapeutic Medicine·Feng-Hua LvSu-Rong Zhang
Feb 12, 2021·Life Sciences·Song RenMiao Yuan
Jul 22, 2021·Journal of Inflammation Research·YaLan LuoHaiLong Chen