Protective effect of Letinous edodes foot peptides against ethanol‑induced liver injury in L02 cells

Molecular Medicine Reports
Lin MaJun Lu

Abstract

The aim of the present study was to evaluate the protective effect and mechanism of Letinous edodes foot peptides on ethanol‑induced L02 cells. A cell model of ethanol‑induced damage was established in vitro to study the effects of the Letinous edodes foot peptides on human L02 hepatocytes. The expression and activity of superoxide dismutase (SOD), malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), following treatment were examined to determine the anti‑alcoholism and hepatoprotective functions of Letinous edodes foot peptides. Taking Letinous edodes foot peptides prior to ethanol exposure was more beneficial, which significantly increased SOD activity and the mRNA expression of ADH and ALDH suppressed by ethanol. In addition, the intracellular MDA content, and AST and ALT activity decreased in ethanol‑induced L02 cells pretreated with the peptides, when compared with the control. Furthermore, Letinous edodes foot peptides inhibited the ethanol‑induced activation of the proinflammatory cytokines, interleukin‑6 and tumor necrosis factor‑α, and promoted the metabolic regulation factors, AMP‑activated protein kinase‑α2 and pero...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 29, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wen-hu LiuMei-chin Yin
Jan 28, 2010·Alcoholism, Clinical and Experimental Research·Andrew M MillerBin Gao
Apr 24, 2010·Nuclear Receptor Signaling·Sean R PyperJanardan K Reddy
Sep 4, 2010·PPAR Research·Woo Hyung Lee, Sang Geon Kim
Sep 4, 2010·Gastroenterology Research and Practice·Sarah M DenucciSuzanne M de la Monte
Apr 13, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jin-Zhe HePei-Long Sun
Jan 25, 2014·Journal of Medicinal Food·Hyoung Joon ParkJae-Hyeon Cho
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Xiao ChenChao Liu
Apr 17, 2015·BMC Complementary and Alternative Medicine·Liqin WangLe Jia
Sep 26, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Zibiao ZhongQifa Ye
Feb 29, 2016·Molecular Immunology·Rebecca L SmathersLaura E Nagy
Mar 19, 2016·Journal of Toxicologic Pathology·Sarawoot PalipochPrasit Suwannalert
Nov 5, 2016·International Journal of Biological Macromolecules·Yong-Ming ZhaoLi-Xia Shen
Feb 9, 2017·International Journal of Biological Macromolecules·Lijun ZhangBing Zhao
May 21, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengyao ZhaoHing Man Chan
Jun 2, 2017·BioMed Research International·Tong ZhouHua-Bin Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.