PMID: 9164663Feb 1, 1997Paper

Protective effect of magnesium supplementation on experimental 3-methyl cholanthrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats

Biological Trace Element Research
T PatiroğluR Saraymen

Abstract

In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholanthrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p < 0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anti-carcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis.

References

Feb 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G A Young, F M Parsons
Jan 1, 1989·Oncology·M DíezJ L Balibrea
Apr 1, 1984·The Journal of Nutrition·B J MillsR D Lindeman

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Citations

Apr 11, 2001·Mutation Research·A Hartwig
Jun 10, 2014·Nutrition and Cancer·Hae Jin KoWon Kee Lee
Aug 26, 2016·Genetics and Molecular Biology·Gulsen Uz, Aysegul Topal Sarikaya
Feb 13, 2021·Nutrients·Mario BarbagalloLigia J Dominguez

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