Protective effect of Matricaria chamomilla on ethanol-induced acute gastric mucosal injury in rats

Pharmaceutical Biology
Mustafa CemekMehmet Emin Büyükokuroğlu

Abstract

The antiulcerogenic and antioxidant properties of Matricaria chamomilla L. (Compositae) hydroalcoholic extract (MCE) on ethanol-induced gastric mucosal injury were investigated in rats. After the induction of gastric mucosal injury, all groups were sacrificed; the gastric ulcer index was calculated, and malondialdehyde (MDA) and reduced glutathione (GSH) in whole blood and gastric tissue, and serum ascorbic acid, retinol, and beta-carotene levels were measured in all groups. Pretreatment with MCE at some doses significantly reduced gastric lesions. Again, some doses of MCE significantly reduced the MDA, and significantly increased GSH levels in gastric tissue or whole blood. Serum beta-carotene and retinol levels were significantly higher in the 200 mg/kg MCE-administered group with respect to control. As a result, MCE clearly has a protective effect against ethanol-induced gastric mucosal lesions, and this effect, at least in part, depends upon the reduction in lipid peroxidation and augmentation in antioxidant activity.

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Citations

Oct 11, 2015·Pharmaceutical Biology·Zainul Amiruddin ZakariaMohd Zaki Salleh
Jul 10, 2012·Journal of Ethnopharmacology·Kátia Wolff CordeiroKarine de Cássia Freitas
Jun 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rafael Porto IneuMaria Ester Pereira
Dec 28, 2019·Mini Reviews in Medicinal Chemistry·Hamidreza ArdalaniAmirhossein Sahebkar

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