Protective effect of melatonin against formaldehyde-induced kidney damage in rats

Toxicology and Industrial Health
I ZararsizE Ozan

Abstract

This study was undertaken to investigate the protective effects of melatonin against formaldehyde-induced renal damage in rats. For this purpose, 21 male Wistar rats were divided into three groups. The animals in Group I were used as a control, whereas the rats in group II were injected every other day with formaldehyde. The rats in group III received melatonin daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation, and the kidneys were removed. Some of the renal tissue specimens were used for determination of superoxide dismutase, glutatione peroxidase enzyme activities, and malondialdehyde levels. The remaining kidney tissue specimens were used for light microscopic evaluation. The renal tissue activities of superoxide dismutase and glutatione peroxidase were significantly decreased, and malondialdehyde levels were significantly increased in rats treated with formaldehyde compared with those of the control animals. In the light microscopic evaluation of this group, degenerative glomerules, vacuolization and dilatation of distal tubules, and vascular congestion were detected. However, an increase was observed in activities of superoxide dismutase and glutatione p...Continue Reading

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Citations

Aug 21, 2014·Oxidative Medicine and Cellular Longevity·Borut Poljšak, Rok Fink
Sep 17, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·E BakarA Cerkezkayabekir
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Mar 30, 2011·Toxicology and Industrial Health·Ismail ZararsizSadik Sogut
Mar 23, 2012·Toxicology and Industrial Health·Ufuk TasMustafa Sarsilmaz
Jul 17, 2013·Toxicology and Industrial Health·Sedat MeydanIlter Kus

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