Protective effect of melatonin in the diabetic rat retina

Fundamental & Clinical Pharmacology
Saeed MehrzadiMansoor Shahriari

Abstract

Diabetic retinopathy (DR) is one of the most common and serious microvascular complications of diabetes. The aim of this study was to evaluate the effects of melatonin (MEL) on retinal injury in diabetic rats. In this study, 21 rats were randomly divided into three groups: control, diabetic, and diabetic + MEL. Streptozotocin was used to induce diabetes at a dose of 50 mg/kg, i.p., and blood glucose was measured to choose the diabetic rats for the study. MEL (20 mg/kg) was given orally for 7 weeks in diabetic rats starting 1 week after induction of diabetes. After 8 weeks, the groups were compared in terms of mean scores of fluorescein leakage, using fluorescein angiography. Reactive oxygen species (ROS) and malondialdehyde (MDA) levels were estimated in retina using commercially available assays. Structural changes in retinas were evaluated by light microscopy. Results showed that diabetes significantly increased the mean scores of fluorescein leakage, and MDA and ROS levels compared to control group. Treatment of the diabetic rats with MEL for 7 weeks prevented the alterations induced by diabetes in comparison with the diabetic control group.Based on these findings, it can be concluded that MEL might have beneficial effects i...Continue Reading

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Citations

Jun 5, 2018·Fundamental & Clinical Pharmacology·Amany Abdel-GhaffarRawda G Mohamed
May 18, 2020·Fundamental & Clinical Pharmacology·Karim HematiAzam Hosseinzadeh
Apr 14, 2020·Diabetology & Metabolic Syndrome·Mohammad Hossein PourhanifehSaeed Mehrzadi
Aug 7, 2018·World Journal of Diabetes·Adejoke Y Onaolapo, Olakunle J Onaolapo
Aug 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mengshan HeHongling He
Oct 28, 2020·Expert Opinion on Investigational Drugs·Ashay D Bhatwadekar, Varun Rameswara
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Fareha WajidIan H Rutkofsky
Feb 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuanyuan TuManhui Zhu
Apr 2, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jingjing ZhaoFang Peng
Mar 24, 2018·Life Sciences·Azam HosseinzadehSaeed Mehrzadi
Sep 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nosrat BahramiSaeed Mehrzadi

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