Protective effect of melatonin on liver ischemia-reperfusion induced pulmonary microvascular injury in rats

Transplantation Proceedings
M-H ChiuJ-J Wang

Abstract

Reactive oxygen species generated during liver reperfusion have been implicated in remote lung injury. In this study, we evaluate the protective effects of melatonin pretreatment against the increased pulmonary microvascular permeability. Male Sprague-Dawley rats were divided into three groups: shame-operated, liver ischemia-reperfusion (I/R), and melatonin pretreated (15 mg/kg, intraperitoneally) 15 minutes prior to the liver I/R). The duration of ischemia was 30 minutes, followed by 2 hours of reperfusion. Lungs were isolated in situ and parameters of the capillary filtration coefficient (K(fc)), lung wet-to-dry weight ratio (W/D), lung weight-to-body weight (LW/BW), and protein concentration in bronchial lavage fluid (PCBAL), the percentage of macrophages and neutrophils in bronchial lavage fluid (BALF), and lung tissue malonedealdehyde were used to assess the lung injury. Liver I/R-induced lung injury was noted by the markedly increased K(fc), W/D, LW/BW, PCBAL, and the presence of neutrophils and macrophages in BALF. Lipid peroxidation was also increased (P < .05). All indicators were markedly decreased in melatonin-pretreated rats (P < .05), suggesting that lung injury was attenuated. Melatonin pretreatment prior to liver...Continue Reading

References

Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·V G NielsenD A Parks
Oct 29, 1998·Biochemical and Biophysical Research Communications·H ZhangW A Pryor
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Aug 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Georgios K GlantzounisAlexander M Seifalian
Mar 16, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·W Jeffrey WeidnerJ David Furlow
Jun 24, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tobias W FischerAndrzej Slominski
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Huseyin OkutanNamik Delibas

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Citations

Dec 8, 2014·The Journal of Surgical Research·Munehito UchiyamaKiyoyasu Kurahashi
Mar 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yanbo WangKe Zen
Aug 28, 2021·International Journal of Molecular Sciences·Adam WichniakWiesław Jerzy Cubała

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