Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats

Fundamental & Clinical Pharmacology
Boxin ShangLei Dong

Abstract

Inflammation of the colon in patients with ulcerative colitis (UC) causes pain and altered motility, at least in part through the damage of the myenteric neurons (MNs). Thus, it is important to evaluate new drugs for UC treatment that could also protect myenteric neurons efficiently. As a well-known neural protective and anti-inflammatory agent, melatonin could protect neurons from damage through the activation of the nuclear factor erythroid 2-related factor 2 and antioxidant responsive element (Nrf2-ARE) signaling pathway. Therefore, we investigated the potential protective effect of melatonin against MN damage during colitis induced by 2,4-dinitrobenzene sulfonic acid (DNBS) in rats. Colitis was induced by intracolonic (i.c.) instillation of DNBS and treated with melatonin at a dose of 2.5 mg/kg for 4 days. The damage of MN in the left colon was immunohistochemically evaluated in different groups. Ulcerations and inflammation in the colon were semiquantitatively observed. Myeloperoxidase (MPO), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were detected to evaluate the inflammatory and oxidative stress status. The protein and mRNA expressions of Nrf2 and heme oxygenase-1 (HO-1) in the colon were detected by We...Continue Reading

References

Nov 11, 1991·Gastroenterology·S N ReddyW J Snape
May 31, 1994·Annals of the New York Academy of Sciences·R J ReiterS Saarela
Aug 15, 1993·Experientia·R J Reiter
Oct 9, 1999·The American Journal of Pathology·S SanovicM G Blennerhassett
Jun 4, 2005·Clinical and Experimental Immunology·G PaulH Herfarth
Aug 16, 2005·Journal of Pineal Research·Cristina Tomás-Zapico, Ana Coto-Montes
Sep 9, 2005·The Journal of Biological Chemistry·Valdecir F XimenesAna Campa
Sep 28, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D R LindenG M Mawe
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Apr 19, 2007·Journal of Pineal Research·Viera Nosál'ováMonika Zakálová
May 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sandra LourenssenMichael G Blennerhassett
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Lysa BoisséAlan E Lomax
Oct 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B ChandrasekharanS Srinivasan
Mar 24, 2011·Journal of Cellular and Molecular Medicine·Nunzia BernardiniAmelio Dolfi
Jul 7, 2011·BMC Health Services Research·Anne PrenzlerJ-Matthias von der Schulenburg
Jul 28, 2011·Fundamental & Clinical Pharmacology·Amit K SharmaSwapan K Bhattacharya
Sep 20, 2011·Fundamental & Clinical Pharmacology·Sergi MasAmalia Lafuente
Dec 8, 2011·Fundamental & Clinical Pharmacology·Amandine RamondMarie Joyeux-Faure
Dec 14, 2011·Fundamental & Clinical Pharmacology·Seda TasdemirAhmet Acet
Jan 16, 2013·Nutrition·Carla Possani CiriloMaria Raquel Marçal Natali
Jun 5, 2013·The Journal of Physiology·Jane A RobertsGary M Mawe
Nov 20, 2013·Inflammatory Bowel Diseases·Gopabandhu Jena, Priyanka P Trivedi
Jan 18, 2014·Experimental Gerontology·João Paulo Ferreira SchoffenMaria Raquel Marçal Natali
Nov 21, 2014·European Journal of Nutrition·Ahlem BoussennaCatherine Felgines
Dec 22, 2014·Molecular and Cellular Endocrinology·Jerry Vriend, Russel J Reiter
Jan 7, 2015·Neurobiology of Disease·Shriram VenkataramanaM G Blennerhassett
Jul 22, 2015·Fundamental & Clinical Pharmacology·Christophe LietMarie-Laure Bocca
Nov 10, 2015·Biochemical Society Transactions·Bryan HarderDonna D Zhang

❮ Previous
Next ❯

Citations

Dec 28, 2016·The British Journal of Nutrition·Javier Ávila-RománVirginia Motilva
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
Feb 13, 2018·Fundamental & Clinical Pharmacology·Azadeh Aminzadeh, Saeed Mehrzadi
Sep 23, 2018·Journal of Pineal Research·Rüdiger Hardeland
Nov 13, 2018·Journal of Pineal Research·Adriana Pérez-GonzálezAnnia Galano
May 18, 2020·Current Drug Targets·Rhian StavelyKulmira Nurgali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.