Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells

Journal of Pineal Research
Hee Jung Um, Taeg Kyu Kwon

Abstract

Melatonin is an indolamine initially found to be produced in the pineal gland but now known to be synthesized in a variety of other tissues as well. The mechanisms whereby melatonin regulates the apoptotic program remain only partially understood. Anti-/pro-apoptotic effects of exogenous melatonin on various stimuli-mediated apoptosis were investigated in this report. We investigated the combined effect of melatonin and death receptor-mediated ligands (TNF-α, TRAIL, and anti-Fas antibody) or endoplasmic reticulum (ER) stress-inducing agents (thapsigargin, brefeldin A, and tunicamycin) on apoptosis of cancer cells. Death receptor- or ER stress-induced apoptosis was not significantly influenced by melatonin treatment. However, pretreatment with melatonin significantly inhibited DNA damage-induced apoptosis and glutathione (GSH) depletion, suggesting the reactive oxygen species mediate oxaliplatin/etoposide-induced apoptosis. Interestingly, we also found the involvement of myeloid cell leukemia-1 (Mcl-1) downregulation in oxaliplatin-induced apoptosis; thus, pretreatment with melatonin inhibited Mcl-1 downregulation, and ectopic expression of Mcl-1 attenuated oxaliplatin-induced apoptosis. Taken together, the results demonstrate t...Continue Reading

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Citations

Oct 22, 2011·Journal of Experimental Botany·Dun-Xian TanRussel J Reiter
Jul 24, 2015·Journal of Pineal Research·Anna FernándezJosé L Mauriz
Apr 26, 2017·Journal of Pineal Research·Maryam MajidiniaBahman Yousefi
May 25, 2016·American Journal of Rhinology & Allergy·Sema KocSalim Yüce
Sep 8, 2018·Journal of Cellular Physiology·Masoud NajafiKeywan Mortezaee
Aug 18, 2018·Expert Opinion on Drug Metabolism & Toxicology·Hamed Haghi-AminjanMohammad Abdollahi
Nov 23, 2017·Oncotarget·Chia-Ming YehShun-Fa Yang
Sep 19, 2020·Cancer Cell International·Mohammad Hossein MehrzadiSaeed Mehrzadi
Apr 20, 2018·Journal of Cellular Physiology·Keywan Mortezaee
Aug 7, 2019·Journal of Experimental & Clinical Cancer Research : CR·Ziqiang ZhangJianjun Du
Mar 2, 2019·International Journal of Molecular Sciences·Biswojit DebnathDongliang Qiu
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswojit DebnathDongliang Qiu
Jul 19, 2021·Reproductive Toxicology·Gaby Judith Quispe PalominoAna Paula Ribeiro Rodrigues
Aug 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arezoo Fathalizadeh AlamdariSarvin Sanaie

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