Abstract
Cyclophosphamide (CP) causes infertility due to ovarian toxicity. The toxicity mechanism suggests oxidative stress. We assessed whether mirtazapine (MTZ) and hesperidin (HSP) could promote ovarian protection against damage due to CP chemotherapy. Female Wistar rats aged 14 weeks were used. Animals were divided into four groups: control vehicle group (n = 8); CP group (n = 8, rats received 150 mg/kg of CP, single intraperitoneal [i.p.] injection); CP + MTZ group (n = 8, rats received same dose of CP + 30 mg/kg of MTZ, orally, daily); and HSP + CP group (n = 8, rats received same dose of CP + 100 mg/kg of HSP, orally, daily). After eight days of medication, ovaries were removed and ovarian toxicity was assessed by counting follicles and corpora lutea. Nitric oxide (NO) and malondialdehyde (MDA) levels, myeloperoxidase (MPO), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities were estimated in ovarian tissue. NO level, MDA level, and MPO activity were increased (P < 0.001), while, GPx and SOD activities were lowered significantly (P < 0.001) in CP-treated group compared with control vehicle. In addition, ovulation, number of follicles, and ovarian weight were reduced by CP treatment. On the contrary, rats pret...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1992·Reproductive Toxicology·D R PlowchalkD R Mattison
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jun 28, 2000·Analytical Biochemistry·L A RidnourD R Spitz
Jan 3, 2001·Molecular Human Reproduction·A B MottaA M Franchi
Feb 20, 2004·Biochemistry. Biokhimii︠a︡·J Arnhold
Jun 9, 2005·Journal of Agricultural and Food Chemistry·Patricia Kelly WilmsenMirian Salvador
Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalRakesh K Sharma
Sep 3, 2005·Reproductive Biology and Endocrinology : RB&E·Junichi FujiiFutoshi Okada
Sep 13, 2006·Archives of Pharmacal Research·Jungsook Cho
May 9, 2007·DNA Repair·Ryan J HansenM Eileen Dolan
Apr 29, 2008·Toxicologic Pathology·F Russell Westwood
May 21, 2010·Reproductive Biology and Endocrinology : RB&E·Claudia N C D LemosAroldo F Camargos
Jun 24, 2011·Biology of Reproduction·Connie J Mark-KappelerPatrick J Devine
Oct 29, 2011·Biology of Reproduction·Patrick J DevineUlrike Luderer
Dec 21, 2011·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Natarajan Nandakumar, Maruthaiveeran Periyasamy Balasubramanian
Jun 14, 2013·Biochemistry Research International·Nese Arzu YenerFehime Aksungar
Citations
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Ting ZhangZuyue Sun
Sep 30, 2016·Reproduction, Fertility, and Development·Naglaa F Khedr
Oct 11, 2019·Human Reproduction Update·N SpearsF G Klinger
Sep 25, 2019·International Journal of Molecular Sciences·Xia HaoKenny A Rodriguez-Wallberg
Aug 18, 2018·Aging·Xingting LiuCaiqiao Zhang
Mar 16, 2018·Oxidative Medicine and Cellular Longevity·Xingting LiuCaiqiao Zhang
Mar 21, 2019·Drug and Chemical Toxicology·Amr A FouadManal I Abdelghany
Jun 17, 2020·Drug and Chemical Toxicology·Vadakkepurath Raj AthiraHanumant Narasinhacharya Yajurvedi
Feb 21, 2019·Experimental Biology and Medicine·Hamed ShooreiHamidreza Pazoki-Toroudi
Mar 12, 2020·Veterinary World·Dhanya Venugopalan NairU Rajkumar
Apr 2, 2019·Ultrastructural Pathology·Ereny FekrySamy Makary
Aug 3, 2019·Human & Experimental Toxicology·M A ElkadyS El-Mandouh
May 28, 2020·Toxicology Mechanisms and Methods·Asmaa Mohamed Abdel-AzizMaha Yehia Kamel
Jun 2, 2020·Frontiers in Pharmacology·Mei JiangTing Wang
Nov 27, 2020·Journal of Ovarian Research·Soghra BahmanpourNehleh Zarei-Fard
Dec 25, 2019·Reproductive Toxicology·Laura Silveira AyresElizabeth Obino Cirne-Lima
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alaa E El-SisiNermine M Abdelsalam
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eman M MantawyAmal Kamal Abdel-Aziz
Apr 2, 2021·Frontiers in Cell and Developmental Biology·Penghui FengQi Yu
May 1, 2021·Journal of Clinical Medicine·Kenny A Rodriguez-WallbergFrida E Lundberg
May 7, 2021·Journal of Oleo Science·Jin LiuYijuan Liang
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Felix Kwame AmevorXiaoling Zhao
Oct 14, 2021·Reproductive Sciences·Ricássio S BarberinoMaria Helena T Matos
Nov 4, 2021·The Journal of Obstetrics and Gynaecology Research·Qin WangShiyan Sui