Protective effect of mirtazapine and hesperidin on cyclophosphamide-induced oxidative damage and infertility in rat ovaries

Experimental Biology and Medicine
Naglaa Fathi Khedr

Abstract

Cyclophosphamide (CP) causes infertility due to ovarian toxicity. The toxicity mechanism suggests oxidative stress. We assessed whether mirtazapine (MTZ) and hesperidin (HSP) could promote ovarian protection against damage due to CP chemotherapy. Female Wistar rats aged 14 weeks were used. Animals were divided into four groups: control vehicle group (n = 8); CP group (n = 8, rats received 150 mg/kg of CP, single intraperitoneal [i.p.] injection); CP + MTZ group (n = 8, rats received same dose of CP + 30 mg/kg of MTZ, orally, daily); and HSP + CP group (n = 8, rats received same dose of CP + 100 mg/kg of HSP, orally, daily). After eight days of medication, ovaries were removed and ovarian toxicity was assessed by counting follicles and corpora lutea. Nitric oxide (NO) and malondialdehyde (MDA) levels, myeloperoxidase (MPO), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities were estimated in ovarian tissue. NO level, MDA level, and MPO activity were increased (P < 0.001), while, GPx and SOD activities were lowered significantly (P < 0.001) in CP-treated group compared with control vehicle. In addition, ovulation, number of follicles, and ovarian weight were reduced by CP treatment. On the contrary, rats pret...Continue Reading

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Citations

Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Ting ZhangZuyue Sun
Sep 30, 2016·Reproduction, Fertility, and Development·Naglaa F Khedr
Oct 11, 2019·Human Reproduction Update·N SpearsF G Klinger
Sep 25, 2019·International Journal of Molecular Sciences·Xia HaoKenny A Rodriguez-Wallberg
Mar 16, 2018·Oxidative Medicine and Cellular Longevity·Xingting LiuCaiqiao Zhang
Mar 21, 2019·Drug and Chemical Toxicology·Amr A FouadManal I Abdelghany
Feb 21, 2019·Experimental Biology and Medicine·Hamed ShooreiHamidreza Pazoki-Toroudi
May 28, 2020·Toxicology Mechanisms and Methods·Asmaa Mohamed Abdel-AzizMaha Yehia Kamel
Dec 25, 2019·Reproductive Toxicology·Laura Silveira AyresElizabeth Obino Cirne-Lima
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alaa E El-SisiNermine M Abdelsalam
May 1, 2021·Journal of Clinical Medicine·Kenny A Rodriguez-WallbergFrida E Lundberg
Nov 4, 2021·The Journal of Obstetrics and Gynaecology Research·Qin WangShiyan Sui

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Methods Mentioned

BETA
MDA

Software Mentioned

Statistical Package for Social Sciences ( SPSS

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