Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons

Japanese Journal of Pharmacology
A AkaikeY Tamura

Abstract

This study was performed to examine the neuroprotective action of 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro [2,3-b]quinolin-4-yl)acetoamide (MKC-231), which enhances choline uptake and acetylcholine release in the central nervous system. Glutamate neurotoxicity was assessed with cortical cultures obtained from fetal rats. Exposure of cultures to MKC-231 for 12-24 hr ameliorated glutamate cytotoxicity. MKC-231 reduced cytotoxicity induced by ionomycin, a calcium ionophore, but did not affect the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO) donor. These findings suggest that MKC-231 protects against glutamate neurotoxicity by suppressing the NO formation triggered by Ca2+-influx.

References

Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Jan 1, 1985·Journal of Neurochemistry·S Tucek

❮ Previous
Next ❯

Citations

Jun 1, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masaaki Hirouchi
May 1, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yukihiko ShirayamaRyuzou Kawahara
Feb 15, 2000·Journal of Cardiovascular Pharmacology·Y OkadaE Kobayshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.