Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats.

Redox Report : Communications in Free Radical Research
Khalid S Al NumairArul Albert Baskar

Abstract

Altered mitochondrial function and free radical-mediated tissue damage have been suggested as an important pathological event in isoproterenol (ISO)-induced cardiotoxicity. This study was undertaken to know the preventive effect of morin on mitochondrial damage in ISO-induced cardiotoxicity in male Wistar rats. Myocardial infarction (MI) in rats was induced by ISO (85 mg/kg) at an interval of 24 hours for 2 days. Morin was given to rats as pre-treatment for 30 days orally using an intragastric tube. ISO-treated rats showed a significant elevation of mitochondrial thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP) level and pre-treatment with morin significantly prevented the increase of TBARS and HP level to near normality. The level of enzymic and non-enzymic antioxidants was decreased significantly in ISO-treated rats and pre-treatment with morin significantly increased the levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, and reduced glutathione to normality. The activities of mitochondrial enzymes such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase were decreased si...Continue Reading

References

Feb 1, 1985·Journal of Molecular and Cellular Cardiology·D E ChambersJ M Downey
Oct 17, 1968·European Journal of Biochemistry·W G Niehaus, B Samuelsson
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Jan 31, 1997·International Journal of Cardiology·S R Maxwell, G Y Lip
Feb 7, 2002·The Journal of Pharmacy and Pharmacology·Venkatachalem SathishThiruvengadam Devaki
Jul 12, 2002·Japanese Journal of Clinical Oncology·Ebubekir BakanMetehan Gumus
Oct 10, 2002·The Journal of Biological Chemistry·Karim S EchtayMartin D Brand
Dec 18, 2002·The Journal of Laboratory and Clinical Medicine·Ravinder J Singh
Apr 24, 2003·Molecular and Cellular Biochemistry·Aindrila ChattopadhyayAsoke G Datta
Oct 1, 1952·The Biochemical Journal·E C SLATER, W D BORNER
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Nov 19, 2003·Molecular and Cellular Biochemistry·Robert T Mallet, Jie Sun
May 12, 2004·Free Radical Biology & Medicine·Jian LiJohn W Eaton
Jul 1, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K H Sabeena FarvinT K Thankappan
Jun 30, 2006·Neurobiology of Disease·Miroslav GottliebCarlos Matute
Sep 9, 2006·The Journal of Biological Chemistry·Hidetoshi NojiriTakuji Shirasawa
Mar 16, 2007·The New England Journal of Medicine·Stefan Neubauer
Oct 24, 2007·Chemico-biological Interactions·Venkatabalasubramanian SivaramakrishnanSivasitambaram Niranjali Devaraj
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Andrew J MurrayKieran Clarke

❮ Previous
Next ❯

Citations

Sep 10, 2016·BMC Complementary and Alternative Medicine·Abdelaaty A ShahatLuc Pieters
Jan 23, 2019·Molecular Biology Reports·Vipin Kumar VermaDharamvir Singh Arya
Apr 17, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Gehan Hussein HeebaMohamed Montaser Khalifa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.