Abstract
Long-term treatment with haloperidol, a typical neuroleptic, induces neurodegeneration caused by excitotoxicity and oxidative stress, which play an important role in the development of orofacial dyskinesia. In the present investigation, an attempt has been made to examine the effect of a concomitant treatment of methanol extract of Morus alba Linn. (Moraceae) leaves (100-300 mg/kg, i.p.) and haloperidol (1 mg/kg, i.p.) on an animal model of tardive dyskinesia. Rats were treated for 21 days with haloperidol and Morus alba extract; vacuous chewing movements and tongue protrusions were counted. The extract attenuated the increase in vacuous chewing movements and tongue protrusions induced by haloperidol, which were quantified on day 22. The extract showed a marked effect on behavioral parameters altered by haloperidol treatment. Similar treatment with extract attenuated haloperidol-induced lipid peroxidation and nitrite and normalized superoxide dismutase, catalase, and protein in comparison to the control group. The results suggest a protective effect of Morus alba extract against haloperidol-induced orofacial dyskinesia and oxidative stress.
References
Feb 1, 1978·Archives of Biochemistry and Biophysics·Y Kono
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Wolfarth, K Ossowska
Aug 1, 1985·Chemical & Pharmaceutical Bulletin·T FukaiK Fukushima
Jun 1, 1966·The Biochemical Journal·E D Wills
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 1, 1994·Psychopharmacology·O A Andreassen, H A Jørgensen
Mar 11, 1999·Archives of Pharmacal Research·S Y KimY C Kim
Jan 29, 2000·Journal of Neural Transmission·H IkedaA R Cools
Apr 5, 2000·Progress in Neurobiology·O A Andreassen, H A Jørgensen
Feb 24, 2001·Journal of Neural Transmission·R GaliliD Offen
May 16, 2002·British Journal of Pharmacology·Pattipati S NaiduShrinivas K Kulkarni
Oct 23, 2002·Planta medica·Hyuncheol OhYoun-Chul Kim
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marilise E BurgerJoão B T Rocha
Aug 26, 2003·Journal of Medicinal Food·Pattipati S NaiduShrinivas K Kulkarni
Nov 25, 2003·Fitoterapia·Toshio FukaiHiroshi Sakagami
Mar 30, 2005·The Journal of Nutrition·Byambaa EnkhmaaYosuke Yamane
May 12, 2005·Journal of Ethnopharmacology·Abdel Nasser B SingabToshio Fukai
Nov 30, 2005·Life Sciences·Hesham A El-BeshbishyKalevi Pihlaja
Feb 8, 2006·Biological & Pharmaceutical Bulletin·Tong Ho KangSun Yeou Kim
Jan 1, 2008·Indian Journal of Pharmacology·J P YadavA S Dangi
Jan 1, 2008·Indian Journal of Pharmacology·A V YadavV S Nade
Citations
Apr 23, 2014·Psychopharmacology·Josh ListerGary Remington
Jan 7, 2016·Neurochemical Research·Larissa Finger SchafferCaroline Wagner
Feb 18, 2015·Biological Trace Element Research·Maikel KronbauerMarilise E Burger
Aug 24, 2013·Biological & Pharmaceutical Bulletin·Seungheon LeeJi Wook Jung