Protective effect of N-acetylcysteine on experimental chronic lead nephrotoxicity in immature female rats

Human & Experimental Toxicology
L WangJianzhu Liu

Abstract

Oxidative stress plays a key role in lead (Pb)-induced nephrotoxicity. N-acetylcysteine (NAC) is a potent oxygen free radicals scavenger and a metal chelator. In the present study, female Sprague-Dawley rats received PbAc(2) (300 mg/L, via drinking water) and/or NAC (100 mg/kg/day, by intraperitoneal injection) to investigate the protective effect of NAC on Pb-induced renal damage and oxidative stress as well as its mechanism of action. Renal toxicity was evaluated by measuring urinary excretion of total protein, beta(2)-microglobulin, albumin and urinary enzyme markers of tubular necrosis, as well as serum urea nitrogen level. Activities of antioxidant enzymes, contents of glutathione and malondialdehyde in kidney were also measured. Renal cell damage was assessed by electron microscopy. Animals that received both Pb and NAC showed a better renal function than those receiving Pb alone. Lead-induced tubular lesions and mitochondrial damage were markedly reduced in rats that also received NAC. Also, NAC significantly reduced the levels of lipid peroxidation and markedly restored the enzymic and non-enzymatic antioxidants levels in kidney of Pb-treated rats. Moreover, NAC administration significantly increased urinary Pb excretio...Continue Reading

References

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Citations

Jun 5, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sławomir KasperczykEwa Birkner
Dec 17, 2011·Toxicology and Applied Pharmacology·Chan-Min LiuYun-Zhi Sun
Jul 27, 2011·Environmental Toxicology and Pharmacology·Chan-Min LiuYun-Zhi Sun
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Levent AltintaşEmre Arslanbaş
Jan 15, 2013·Human & Experimental Toxicology·Lin WangZhenyong Wang
Sep 10, 2018·Biological Trace Element Research·Tongsen ZhangJiandong Tai

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