Protective effect of nifedipine against carrageenan-induced inflammation

Pharmacology
S SánchezM E Planas

Abstract

Administration of carrageenan (CA; 0.5 mg) to the plantar tissue of rats resulted in reversible inflammatory injury. The edema was monitored by changes in paw volume using a plethysmometer. Simultaneous administration of CA and nifedipine, intraperitoneally, at different doses (10, 20 and 50 mg/kg) prevented the inflammatory action, and the effect was dose- and time-dependent. In order to improve the nifedipine effects, we prepared liposomed nifedipine which, administered intraperitoneally, showed a greater anti-inflammatory action. In the presence of the L-type channel agonist Bay K 8644, the inflammation produced by CA increased and it was counteracted by free or liposomed nifedipine. The significance of these findings with respect to the mechanism of the anti-inflammatory action of nifedipine is discussed.

Citations

Nov 7, 2007·The Tohoku Journal of Experimental Medicine·Víctor Manuel Mendoza-NúñezJosé Luis Muñoz-Sánchez
Dec 14, 2005·Journal of Ethnopharmacology·Shabana Channa Atta-Ur-Rahman
Sep 1, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D BiliciS Altaş
Apr 12, 2007·Archives of Pharmacal Research·Ishfaq Ali BukhariViqar Uddin Ahmad
Jan 4, 2019·Metabolic Brain Disease·Neetu SainiRajat Sandhir

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