Protective effect of nitric oxide in an endotoxin-induced septic shock

American Journal of Surgery
J H ParkS H Shin

Abstract

Calcium ion (Ca++)-independent nitric oxide (NO) synthase activity in animals was markedly induced by treatment with endotoxin, but NO levels in various tissues removed from endotoxin-treated animals have not been reported. The role of NO during an endotoxin-induced septic shock remains controversial. ICR mice, randomly divided into one of six treatment groups, received intraperitoneal injections as follows: phosphate-buffered saline; Escherichia coli LPS (LPS); N(omega)-nitro-L-arginine (L-NNA); N(omega)-nitro-D-arginine (D-NNA); LPS plus L-NNA; and LPS plus D-NNA. The mice were either monitored for mortality or killed for nitrite/nitrate assays and histologic analysis. NO levels in many tissues were markedly increased by injection of LPS, and administration of L-NNA increased mortality rates of LPS-treated mice, in association with an increase in tissue damage in the lung, liver, and kidney. The endogenous NO generated during LPS-mediated septic shock could be protective.

References

Dec 31, 1991·Biochemical and Biophysical Research Communications·G M RubanyiL H Botelho
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Nov 1, 1991·Annals of Surgery·J B OchoaA B Peitzman
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiJ Vane
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Dec 15, 1989·Biochemical and Biophysical Research Communications·M PalaciosS Moncada
Nov 15, 1993·Biochemical and Biophysical Research Communications·S LiuT W Evans
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A GellerT R Billiar
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KoprowskiB Dietzschold
Feb 1, 1994·Archives of Surgery·E A MinnardJ M Daly
Mar 1, 1993·Free Radical Biology & Medicine·S S LloydP B McCay
May 1, 1993·Critical Care Medicine·M C VespasianoJ J Zimmerman

❮ Previous
Next ❯

Citations

May 10, 2006·Digestive Diseases and Sciences·Laura Iris Cosen-BinkerOsvaldo Tiscornia
Mar 16, 2002·The British Journal of Nutrition·U SuchnerK Peter
Oct 16, 2004·Critical Care Medicine·Yvette C LuikingNicolaas E Deutz
Oct 21, 2006·Critical Care Medicine·Paul E Marik
Jan 10, 2002·Biochemical and Biophysical Research Communications·Dominique TalletJean-Luc Burgaud
Apr 27, 2002·American Journal of Surgery·Peter B SoetersNicolaas E P Deutz
Jul 4, 2003·British Journal of Pharmacology·Fusun TuresinJohn L Wallace
Oct 12, 2000·The Journal of Surgical Research·T C Hua, S M Moochhala
Oct 27, 1999·The Journal of Surgical Research·C F Bellows, B M Jaffe
Sep 24, 2004·Current Opinion in Critical Care·Yoram VodovotzGary An
Aug 17, 2006·Shock·Yoram VodovotzGilles Clermont
Jul 1, 2005·Shock·Carson C ChowYoram Vodovotz
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MojenaL Bosca
Oct 29, 2000·Journal of Applied Physiology·E WielB Vallet
Jan 11, 2000·Clinical Orthopaedics and Related Research·S A CorbettS P Hughes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.