Protective effect of nitric oxide synthase inhibition or antioxidants on brain oxidative damage caused by intracerebroventricular arginine administration

Brain Research
Débora DelwingAngela T S Wyse

Abstract

We have previously demonstrated that acute arginine administration induces oxidative stress and compromises energy metabolism in rat hippocampus. In the present study, we initially investigated the effect of intracerebroventricular infusion of arginine (0.1, 0.5 and 1.5 mM solution) on Na(+),K(+)-ATPase activity and on some parameters of oxidative stress, namely thiobarbituric acid-reactive substances (TBA-RS) and total radical-trapping antioxidant parameter (TRAP) in the hippocampus of rats. Results showed that 1.5 mM arginine solution significantly increases TBA-RS and reduces Na(+),K(+)-ATPase activity and TRAP in the rat hippocampus. We also evaluated the influence of the nitric oxide synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), and antioxidants, namely alpha-tocopherol plus ascorbic acid, on the effects elicited by arginine on Na(+),K(+)-ATPase activity, TBA-RS and TRAP. Results showed that treatment with alpha-tocopherol plus ascorbic acid per se did not alter these parameters but prevented these effects. Furthermore, intracerebroventricular infusion of L-NAME prevented the inhibition caused by arginine on Na(+),K(+)-ATPase activity, as well as the increased of TBA-RS. Our findings indicate that in...Continue Reading

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Citations

Sep 13, 2011·Neurochemical Research·Eduardo von Poser ToigoCarla Dalmaz
Jul 6, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniela Delwing-de LimaDébora Delwing-Dal Magro
Aug 29, 2018·Journal of Food Science and Technology·Ramandeep KaurAmarjeet Kaur
Apr 3, 2016·Journal of Inherited Metabolic Disease·Martina HuemerDaniela Karall
Aug 5, 2016·Journal of Biochemical and Molecular Toxicology·Daniela Delwing-de LimaAngela Terezinha de Souza Wyse
Jan 8, 2011·Fundamental & Clinical Pharmacology·Daniela Delwing de LimaDébora Delwing-Dal Magro
Aug 3, 2021·Metabolic Brain Disease·Narueporn LikhitweerawongSiriporn C Chattipakorn

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