PMID: 11090993Nov 25, 2000

Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice

Journal of Ethnopharmacology
J XuJ Shen


The protective effect of Oren-gedoku-to (OGT; Huang-Lian-Jie-Du-Tang), a traditional Chinese medicine, against impairment of learning and memory induced by transient cerebral ischemia was investigated in mice. The cerebral ischemia caused a reduction of step-down latency and an increase of step-down errors in the passive avoidance task. Pretreatment with oral administration of OGT (2, 4 or 8 g of herbs per kg) once daily for 5 days prolonged the step-down latency significantly and decreased the step-down errors as compared with those of sham-operated controls. In the Morris water maze test, the cerebral ischemia caused an increase in the latency until finding the platform in the training trial and a decrease in the percentage of swimming in the quadrant of the former platform in the probe trial. Oren-gedoku-to (OGT; 2, 4 and 8 g/kg, p. o.) shortened the latency of escaping markedly onto the platform in the training trial and increased the percentage of crossing the former platform quadrant in the probe trial. A reference drug, tacrine (0.5 and 1.0 mg/kg, p.o.), prevented the reduction of step-down latency in the passive avoidance task and shortened the escape latency in the Morris water maze task. Furthermore, OGT significantly...Continue Reading


May 1, 1984·Journal of Neuroscience Methods·R Morris
Jan 1, 1981·Journal of Neurochemistry·G E Gibson, T E Duffy
Dec 1, 1994·Stroke; a Journal of Cerebral Circulation·M HirakawaK Sano
Jan 1, 1993·The American Journal of Chinese Medicine·H MizukawaE Haruki
Jun 1, 1993·Annals of Neurology·T K TatemichiJ P Mohr
Feb 1, 1997·Stroke; a Journal of Cerebral Circulation·P B Gorelick


Apr 26, 2003·Bioorganic & Medicinal Chemistry·Opa VajraguptaNaparat Kammasud
May 30, 2002·Biological Chemistry·Kuresh A YoudimCatherine Rice-Evans
Apr 23, 2005·Neurological Research·Hocheol Kim
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Haiyang FangJing Zhao
Jun 13, 2014·Phytotherapy Research : PTR·Effat BehravanHossein Hosseinzadeh
Jul 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Fafeng ChengQingguo Wang
Sep 23, 2014·Behavioural Brain Research·Thenmoly DamodaranHans C Dringenberg
Dec 1, 2012·Current Therapeutic Research, Clinical and Experimental·Quan YiJian-Dong Luo
May 5, 2011·Expert Opinion on Therapeutic Patents·Abraham LópezErnest Giralt
Apr 17, 2015·BMC Complementary and Alternative Medicine·Chang-Seob SeoHyeun-Kyoo Shin
May 1, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Huaxu ZhuYuping Tang
Dec 16, 2005·The American Journal of Chinese Medicine·Xueli WangLijun Du
Dec 28, 2016·Journal of Immunoassay & Immunochemistry·Madan Kumar PaudelSatoshi Morimoto
Jan 29, 2019·Frontiers in Pharmacology·Kyungho KimKwang-Il Park
Nov 28, 2019·Frontiers in Pharmacology·Pengqian WangFeng Sui
Apr 1, 2020·The Journal of International Medical Research·Wenbin WuXuehui Liu

Related Concepts

Acetilcolina Cusi
Crescendo Transient Ischemic Attacks
Plant Extracts, Chinese
Learning Disturbance
Mouse, Inbred ICRC
Mouse, Swiss

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.