Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide.

Journal of Bioenergetics and Biomembranes
Kavita K Kumari, O H Setty

Abstract

The evolving role of mitochondria, in mediating chemotherapy-induced apoptosis motivated us for the studies described here. The combination of cisplatin and cyclophosphamide is widely used in treating various types of cancers. The purpose of our study was to understand the mechanism of the toxicity induced by the co-administration of cisplatin and cyclophosphamide, on mitochondrial bioenergetics, and to study the protective effect of prior administration of the medicinal plant extract Phyllanthus fraternus. Our results reveal that co-administration of cisplatin (12 mg/kg, i.p) and cyclophosphamide (150 mg/kg, oral) to wistar rats (100 g) significantly alters mitochondrial structure and hence function. The rate of mitochondrial respiration was decreased significantly with both NAD + and FAD-linked substrates. The respiratory control ratio, an index of membrane integrity and the P/O ratio, a measure of phosphorylating efficiency also were decreased significantly accompanied by elevation in the lipid peroxide levels in liver, kidney homogenate and liver mitochondria respectively. Also, the phospholipid content of the mitochondrial membrane, showed a significant decrease, indicating mitochondrial membrane changes. Prior administrat...Continue Reading

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Citations

Aug 5, 2014·BMC Complementary and Alternative Medicine·Abdulrahman L Al-Malki, Ahmed Amir Radwan Sayed
Mar 29, 2014·TheScientificWorldJournal·Bharti SarinAparajita Mohanty
Aug 5, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ludovic PeyreRoger Rahmani
Jul 10, 2014·Journal of Receptor and Signal Transduction Research·Kavita Kumari Kakarala, Kaiser Jamil
May 6, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wylly Ramsés García-Niño, Cecilia Zazueta
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Jan 21, 2017·Archives of Biochemistry and Biophysics·Heba H MansourShereen M Galal
Oct 5, 2017·Journal of Nephropathology·Saeid Heidari-SoreshjaniAli Saeedi-Boroujeni
Nov 22, 2018·Frontiers in Pharmacology·Qing-Yu ZhangLing-Dong Kong

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