PMID: 9820126Nov 20, 1998

Protective effect of Picroliv from Picrorhiza kurroa against Leishmania donovani infections in Mesocricetus auratus

Life Sciences
N MittalA K Rastogi

Abstract

The prevalent drugs for treatment of kala azar viz. sodium stibogluconate (SSG) and pentamidine cause severe toxic side effects and acute immunosuppression in the treated individuals. Picroliv, a standardized mixture of iridoid glycosides, prepared from the alcoholic extract of the root and rhizome of Picrorhiza kurroa has shown strong hepatoprotective activity against several models of hepatotoxicity. Therefore, the present study was undertaken with an objective to study the effects of Picroliv (12.5 mg/kg x 7 days oral) alone and in combination with SSG on parasitemia, lipid peroxidation and hepatic marker enzymes of golden hamsters during Leishmania donovani infection. The results indicated a marked hepatoprotective effect of Picroliv in terms of biochemical markers, and a significant antileishmanial activity implying that it can be utilized as an adjunct to chemotherapy or in combination therapy of kala azar along with sodium stibogluconate, thus enhancing the efficacy of antileishmanials.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1988·Experimental Parasitology·J D Berman, M Grogl
Jul 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·N C HepburnP C Hayes
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·W L RobertsP M Rainey
Jan 1, 1995·Annual Review of Microbiology·P Borst, M Ouellette

Citations

Sep 7, 2001·Fitoterapia·P B de Carvalho, E I Ferreira
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·H W Murray
Mar 6, 2010·Expert Opinion on Drug Delivery·Swati GuptaSuresh P Vyas
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L G RochaJ M Barbosa-Filho
May 21, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rupashree Sen, Mitali Chatterjee
Dec 29, 2000·The Journal of Parasitology·F J Oliveira, R Cecchini
Aug 18, 2020·Parasitology Research·Sahar GhodsianZohreh Lasjerdi

Related Concepts

Kutkin
Triostam
Schizonticides
Bilirubin, (4E,15E)-Isomer
Cinnamates
Polychemotherapy
Glucosephosphatase
Glutamate Synthase
Glycosides
Cricetus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.