Protective effect of Pimpinella anisoides ethanolic extract and its constituents on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages

Journal of Medicinal Food
Filomena ConfortiPeter J Houghton

Abstract

The present study shows for the first time the chemical profile and the in vitro properties (antioxidant and inhibition of nitric oxide [NO] production) of the aromatic plant Pimpinella anisoides V Brig. (Family Apiaceae). The ethanolic extract of the fruits is characterized by 23 major components. Fourteen monoterpenes, two sesquiterpenes, one fatty acid, five methyl esters and one aldehyde were identified. Among them the most abundant components were the monoterpenes trans-anethole (54.5%), limonene (13.5%), and sabinene (4.4%). The extract showed significant antioxidant activity (50% inhibitory concentration [IC(50)], 3.02 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl test. The test for inhibition of NO production was performed using the murine monocytic macrophage cell line RAW 264.7. The ethanolic extract had significant activity with an IC(50) value of 72.7 microg/mL, and this might indicate that it would have an anti-inflammatory effect in vivo. Among the pure compounds that most effectively inhibited lipopolysaccharide-induced NO production were the most abundant constituents, trans-anethole and limonene, with IC(50) values of 102.7 microg/mL and 70.1 microg/mL, respectively. The cytotoxic effect of P. anisoides extrac...Continue Reading

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Citations

Aug 22, 2013·Natural Product Research·Mariangela MarrelliFrancesco Menichini
Apr 30, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sangwoo RyuIn-Young Choi
Apr 23, 2015·Asian Pacific Journal of Tropical Medicine·Arunagirinathan KoodalingamEthala Subramani Kaviya
May 24, 2016·Journal of Agricultural and Food Chemistry·Renato Pérez-RosésSalvador Cañigueral
Nov 14, 2015·Clinical Nutrition Research·Anjali GanjreVivek Pawar
Nov 15, 2018·Nutrients·Pi-Fen TsuiJenn-Haung Lai
May 27, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Alessandra Mileni Versuti RitterCiomar Aparecida Bersani-Amado
Jan 1, 2012·Biomolecules & Therapeutics·Je Hyeong LeeHyun Pyo Kim
Oct 17, 2020·Chemistry & Biodiversity·Mariangela MarrelliFilomena Conforti
Aug 22, 2013·Journal of Natural Products·Hong-Ik ChoSun-Mee Lee

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