Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats

Journal of Ethnopharmacology
Kasi Pandima DeviThiruvengadam Devaki

Abstract

Hepatic injury elicits intracellular stress that leads to peroxidation of membrane lipids accompanied by alteration of structural and functional characteristics of membrane, which affect the activities of membrane-bound ATPases. The present study appraised the membrane protective effect of Premna tomentosa, a hepatoprotective drug used in Indian traditional medicine. Wistar strain rats were pre-treated with Premna tomentosa extract (750 mg/kg, orally) for 15 days, 24 h prior to administration of acetaminophen (640 mg/kg, orally). During acetaminophen intoxication, the levels of membrane-bound enzymes were significantly decreased, total ATPase (1.63-fold), Mg(2+)ATPase (1.9-fold), Ca(2+)ATPase (1.33-fold) and Na(+)K(+)ATPase (1.73-fold) which was accompanied by changes in the levels of inorganic cations N+, K+ and Ca2+. These alterations were prevented by Premna tomentosa extract pre-treatment, which shows that Premna tomentosa supplementation could exert a beneficial effect against liver injury-induced membrane damage. The potential of the plant might be credited to the presence of antioxidant compound limonene in the plant.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·Y IsraelJ M Phillips
Jul 1, 1990·Basic Research in Cardiology·T MatsuokaK J Kako
Nov 30, 1987·Biochemical and Biophysical Research Communications·G B CorcoranD E Salazar
May 1, 1988·Toxicology and Applied Pharmacology·L L MeyersS D Cohen
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W H GarnerA Spector
Jan 1, 1982·Toxicology·S FairhurstA A Horton
Mar 1, 1995·The International Journal of Biochemistry & Cell Biology·H RauchováZ Drahota
Jul 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M M Reicks, D Crankshaw
May 23, 2002·Seminars in Liver Disease·Neil Kaplowitz
Jun 1, 1951·American Journal of Surgery·C C LOWRYF A HUGHES

❮ Previous
Next ❯

Citations

Mar 30, 2011·European Journal of Nutrition·Jesudoss Victor Antony SantiagoNamasivayam Nalini
Oct 6, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Monika Bhadauria
Oct 22, 2015·Journal of Asian Natural Products Research·K RekhaDas Amitava
May 21, 2011·Pharmaceutical Biology·Nilanjan GhoshSubhash C Mandal
May 11, 2017·Pharmaceutical Biology·Roza Dianita, Ibrahim Jantan
Apr 18, 2021·Journal of Food Science·Reshmi Somanathan KarthigaShashirekha Mysuru Nanjarajurs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved