PMID: 9174979Apr 1, 1997Paper

Protective effect of Rhinax, a herbal formulation, against CCl4-induced liver injury and survival in rats

Journal of Ethnopharmacology
J N Dhuley, S R Naik

Abstract

Rhinax, a herbal formulation, was investigated for its protective activity against CCl4-induced liver injury and survival in rats. Oral administration of Rhinax at a dose of 80 mg/kg significantly reduces the hepatotoxic effects of CCl4. It also significantly improves the survival of rats at a dose of 160 mg/kg. On the basis of these observations, we conclude that Rhinax possesses anti-hepatotoxic activity and that the observed activity may be due to the increased activity of cytochrome P450, thereby exerting an inhibitory effect on reductive pathways of CCl4.

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Citations

Mar 24, 2004·Journal of Ethnopharmacology·M G Rajesh, M S Latha
Feb 25, 1999·Journal of Ethnopharmacology·J N Dhuley, S R Naik
Jul 3, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Bahar AhmedShamshir Khan
Jan 17, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S SreelathaM Umadevi
Oct 11, 2005·Journal of Ethnopharmacology·Guntupalli M Mohana RaoAnnie Shirwaikar
Apr 24, 2013·Asian Pacific Journal of Tropical Medicine·Sunil MistryJ Jena
May 20, 2006·The American Journal of Chinese Medicine·Chao-Ying LeeTai-Hui Chiu
Sep 29, 2007·Clinical and Experimental Pharmacology & Physiology·Ebtehal El-DemerdashNermeen M Shaffie
Feb 5, 2010·International Journal of Food Sciences and Nutrition·Balasubiramanian Kamatchi Kala, Veerabahu Ramasamy Mohan

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