PMID: 20126887Feb 4, 2010Paper

Protective effect of simvastatin in the cyclophosphamide-induced hemorrhagic cystitis in rats

Acta Cirúrgica Brasileira
Anna Carolina Batista DantasAldo Cunha Medeiros

Abstract

Cyclophosphamide (CYP) is an antineoplastic agent used for the treatment of many neoplastic and inflammatory diseases. Hemorrhagic cystitis is a frequent side effect of CYP. Several studies show that simvastatin has important pleiotropic (anti-inflammatory and immunomodulatory) effects. The purpose of the study was to investigate the effect of simvastatin on bladder, ureter and kidney injury caused by CYP. Adult male Wistar rats were randomly divided into three groups. The CYP/SIM group received simvastatin microemulsion by gavage during 7 days (10 mg/kg body wt) before the administration of CYP and the CYP/SAL group rats received saline 0.9%. The control rats were not treated. After that, all rats were treated with a single dose of CYP 200 mg/kg body wt intraperitoneally. The rats were killed 24 h after CYP administration. Plasma cytokines (TNF-alpha, IL-1beta, IL-6) were measured by ELISA. Macro and light microscopic study was performed in the bladder, kidney and ureter. In the bladders of CYP/SIMV treated rats edema of lamina propria with epithelial and sub-epithelial hemorrhage were lower than in CYP/SAL treated rats. The scores for macroscopic and microscopic evaluation of bladder and ureter were significantly lower in CYP...Continue Reading

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Citations

May 23, 2013·Journal of Biochemical and Molecular Toxicology·Osama M Abo-Salem
Oct 21, 2015·The Journal of Nutritional Biochemistry·Raquel D S FreitasMaria M Campos
Jan 24, 2014·ISRN Pharmacology·Najah R HadiSuhaad T Zamil
Jan 19, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D O GonçalvesG S B Viana
Mar 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sara Mohammed Naguib Abdel-HafezWalaa Yehia Abdelzaher
Nov 1, 2018·Revista do Colégio Brasileiro de Cirurgiões·Aldo da Cunha MedeirosMarília Daniela Moreira
Nov 30, 2019·Toxicology Mechanisms and Methods·Shereen M GalalAbeer A Elkhoely
Mar 22, 2019·International Urology and Nephrology·Elif Nur BarutMine Kadioglu
May 28, 2020·Toxicology Mechanisms and Methods·Asmaa Mohamed Abdel-AzizMaha Yehia Kamel
Apr 28, 2021·Immunopharmacology and Immunotoxicology·Mehmet BerközMetin Yıldırım
Jun 3, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amal A El-KholyDina S El-Agamy

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