Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes

Indian Journal of Pharmaceutical Sciences
Vandana S NadeK M Patel

Abstract

The present investigation aimed to evaluate the protective effects of sitagliptin, glimepiride, rosuvastatin and their combinations on oxidative stress and endothelial dysfunction in the aortic tissues in fructose-fed type-2 diabetic rats. Sitagliptin (20 mg/kg, p.o.), glimepiride (2 mg/kg, p.o.), rosuvastatin (5 mg/kg, p.o.) and their combinations were administered for 6 w after induction of diabetes by fructose (66%, w/v solution, p.o. for 8 w) in wistar rats. The effects were examined on body weight, serum glucose, triglyceride, cholesterol, blood pressure, heart rate, nitric oxide and antioxidant defensive enzymes. After completion of treatment schedule, the blood pressure was determined by invasive method and vascular reactivity was tested with adrenaline, noradrenaline and phenylephrine. Endothelial dysfunction was determined by acetylcholine and sodium nitroprusside-induced vasorelaxation studies on isolated rat aortas. Long term treatments significantly decreased body weight gain, serum glucose, triglyceride and cholesterol levels; normalize the heart rate, and blood pressure in fructose fed rats. The treatments significantly improved vascular reactivity to catecholamines with reduction in elevated blood pressure in typ...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Nov 1, 1987·Hypertension·I S HwangG M Reaven
Jun 1, 1966·The Biochemical Journal·E D Wills
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S MargeticR A Hill
Dec 17, 2003·Clinical Biochemistry·Sudesh VasdevVicki Gill
Apr 20, 2005·Current Opinion in Rheumatology·Naveed Sattar, Iain B McInnes
Jul 27, 2006·The Annals of Pharmacotherapy·Shannon Miller, Erin L St Onge

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Citations

Feb 28, 2018·International Journal of Molecular Medicine·Dongdong WangQunli Wei
Apr 20, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Rania G Abdel-LatifMohamed M A Khalifa
Feb 20, 2018·Experimental and Therapeutic Medicine·Wachirawadee MalakulSakara Tunsophon
Nov 5, 2021·Fundamental & Clinical Pharmacology·Reham Hussein MohamedSherin Shafik Tawfik

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