Protective effect of sophocarpine on lipopolysaccharide-induced acute lung injury in mice

International Immunopharmacology
Ying LuLina Gu

Abstract

Sophocarpine (SOP) is a tetracyclic quinolizidine alkaloid isolated from Sophora alopecuroides L. A number of studies have shown that SOP has anti-inflammatory actions and protects against a variety of tissue and organ injuries. The purpose of this study was to investigate the protective effects of SOP on LPS-induced acute lung injury (ALI) in mice. Lung histological alterations, edema, and MPO activity were measured in this study. Furthermore, the production of inflammatory cytokines and the expression of NF-κB and MAPKs signaling pathways were measured. The results showed that the LPS-induced lung histological alterations, edema, protein concentration, inflammatory cell level in BALF, MDA content, and MPO activity were significantly attenuated by SOP. The LPS-induced inflammatory cytokine TNF-α, IL-1β, and IL-6 were also inhibited by SOP. SOP also inhibited the LPS-induced IL-6 and IL-8 production in A549 cells. Western blot analysis demonstrated that SOP remarkably inhibited the phosphorylation of IκBα and NF-κB. LPS-induced MAPKs activation and TLR4 expression were also suppressed by treatment with SOP. In conclusion, the results indicate that SOP protects against LPS-induced ALI by inhibiting TLR4 signaling pathway.

Citations

Jun 17, 2020·Bioscience, Biotechnology, and Biochemistry·Yue-Bao LinJiong-Hua Huang
Mar 5, 2021·Frontiers in Pharmacology·Mohammad Bagher MajnooniJavier Echeverría
Feb 22, 2021·Journal of Ethnopharmacology·Guo-Hui LiHong-Xiang Lou
Mar 11, 2021·Journal of Ethnopharmacology·Xiangting SunLei Chen
Apr 16, 2021·International Immunopharmacology·Wenbing ZhiHong Zhang
Jul 15, 2021·BioMed Research International·Wen-Ying YuChen-Huan Yu

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