Protective effect of Spirulina platensis against cell damage and apoptosis in hepatic tissue caused by high fat diet

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
F YigitE I Ikitimur-Armutak

Abstract

Spirulina platensis is a microalga that may be a source of antioxidants that can reduce body fat deposition. Consumption of a high fat diet produces elevated blood lipid levels, inflammation and apoptosis. We investigated the possible effects of S. platensis on the blood lipid profile, and liver inflammation and apoptosis in rats fed a high fat diet. Sixty-four young male rats were divided into eight equal groups. The control group was fed a basic diet. The experimental groups were fed a diet for 60 days that was prepared by mixing variable amounts of 43% vegetable oil and 10% cholesterol with or without 3% S. platensis mixed with the basal diet. Blood and liver tissue samples were collected from each animal. Serum samples were used to analyze lipid parameters, total antioxidant status and total oxidant status. iNOS and eNOS were determined by immunohistochemistry. TUNEL staining was used to detect apoptosis to investigate a possible connection between inflammation and apoptosis in the liver tissue. The relations between fat deposition and liver degeneration were assessed by Sirius red staining and alpha-smooth muscle actin immunostaining. S. platensis reduced serum HDL-C, LDL-C and triglyceride, increased HDL-C levels in rats ...Continue Reading

References

Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G RamadoriK H Meyer zum Büschenfelde
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A López-De León, M Rojkind
Jan 1, 1995·Journal of Hepatology·J A Pons
Jan 1, 1995·Gastroenterology·G MaliziaJ A McDonald
Oct 1, 1994·Journal of Nutritional Science and Vitaminology·O HayashiY Okuwaki
Jul 1, 1993·Journal of Natural Products·M A Jahromi, A B Ray
Apr 1, 1993·Trends in Genetics : TIG·O Smithies
May 20, 1998·Nutrition·B Alexander
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T K GuptaR J Groszmann
Oct 20, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M S MirandaJ Mancini Filho
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·R M RaiA M Diehl
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T A VosH Moshage
Mar 18, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R GonzálezN Merino
Jul 28, 1999·Molecular Human Reproduction·L M SenturkA Arici
Mar 14, 2001·American Journal of Physiology. Cell Physiology·H Lum, K A Roebuck
Dec 26, 2001·BMC Complementary and Alternative Medicine·M J MillerM Sandoval
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lance McNaughtonMarek W Radomski
May 29, 2003·Current Protein & Peptide Science·Ch RomayV Rimbau
Mar 30, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leon A AdamsKeith D Lindor
Apr 22, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G CarpinoE Gaudio
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Oct 27, 2005·Current Pharmaceutical Biotechnology·Zakir KhanP S Bisen
Nov 1, 2006·The International Journal of Biochemistry & Cell Biology·Shao Chin Lee, Shazib Pervaiz
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Oct 5, 2007·Biological Trace Element Research·Ebru GurelCihan Demirci
Apr 24, 2008·International Journal of Experimental Pathology·Tung-Ming LeungAmin A Nanji
May 13, 2008·Gastroenterology·Scott L Friedman
Oct 16, 2008·Current Pharmaceutical Biotechnology·Archana KulshreshthaP S Bisen
Oct 29, 2008·Seminars in Liver Disease·Harmeet Malhi, Gregory J Gores
Mar 21, 2009·Anesthesia and Analgesia·Chao-Ming ShihTz-Chong Chou
Sep 15, 2009·Toxicology and Applied Pharmacology·Robert DomitrovićIvana Sain
Sep 18, 2009·Molecular Nutrition & Food Research·Sakurako KatsuuraRintaro Yamanishi
Nov 13, 2009·Cell Biochemistry and Function·Elif Ilkay TaşkinEngin Ulukaya
Jan 1, 2008·Nutrition Research and Practice·Eun Hee LeeWha-Young Kim
Jul 17, 2010·Cardiovascular Therapeutics·Ruitang Deng, Te-Jin Chow

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis