Protective effect of taurine against renal interstitial fibrosis of rats induced by cisplatin

Naunyn-Schmiedeberg's Archives of Pharmacology
Shin SatoMasaaki Kurasaki

Abstract

This study was undertaken to investigate the effect of taurine on the infiltration of macrophages and the progression of renal interstitial fibrosis in the kidneys of rats treated with cisplatin (CDDP). Male rats in different groups were treated as follows: (1) saline as control, (2) CDDP and (3) CDDP plus taurine in drinking water. At weeks 2, 4 and 6 after the fifth CDDP injection, we examined platinum content, the kinetics of macrophages and the areas of fibrosis. In the histologic analyses, fibrotic areas were found to have developed around dilated or atrophic tubules in the corticomedullary junction in the kidneys of CDDP-treated rats, while CDDP-plus-taurine-treated rats showed a reduction of the extent and magnitude of damage. These findings reflect the fact that the percentage of fibrotic areas in the kidney of CDDP-plus-taurine-treated rats was significantly lower than in that of CDDP-injected rats throughout the recovery period ( P<0.05). Compared with normal rats, the macrophages in CDDP-injected rats showed significant increases in number at weeks 2, 4 and 6 ( P<0.05). In contrast, the number of macrophages in CDDP-plus-taurine-treated rats was significantly smaller than that of CDDP-injected rats. These results sug...Continue Reading

Citations

Jun 11, 2005·Cancer Chemotherapy and Pharmacology·H LajerT E N Jonassen
Nov 25, 2003·Kidney International·Ernst MalleHermann-Josef Grone
May 1, 2004·Kidney & Blood Pressure Research·Heloísa D Coletta FrancescatoMaria de L P Bianchi
Nov 7, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yolanda I Chirino, José Pedraza-Chaverri
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Jan 22, 2005·Fundamental & Clinical Pharmacology·Göksel SenerGül Ayanoğlu-Dülger
Dec 8, 2009·Journal of Pharmacological Sciences·Yoshiko KawaiMunekazu Gemba
May 26, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Alper OtunctemurNurver Ozbay
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Sep 23, 2020·Nutrients·Tawar QaradakhiAnthony Zulli

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