Protective effect of telmisartan against endothelial dysfunction after coronary drug-eluting stent implantation in hypertensive patients

JACC. Cardiovascular Interventions
Mitsuyasu TerashimaTakahiko Suzuki

Abstract

The aim of this prospective, randomized study was to evaluate the effects of telmisartan, compared with the calcium-channel blocker amlodipine, on endothelial function after coronary drug-eluting stent (DES) implantation in hypertensive patients. DES implantation impairs local endothelial function, which may be associated with future cardiovascular events. Telmisartan, which has unique peroxisome proliferator-activated-receptor-gamma-mediated effects in addition to its renin-angiotensin system-inhibition effects, has favorable effects on endothelial function. Fifty-one hypertensive patients with coronary artery stenosis but without coronary artery spasm, treated with a sirolimus-eluting stent, were randomly assigned to either the telmisartan (25 cases) or amlodipine (26 cases) treatment groups. At baseline and at 3 months after DES implantation, endothelium-dependent and -independent vasomotion were evaluated by quantitative coronary angiography under the condition of medication withdrawal. The mean luminal diameter of a 20-mm coronary segment, beginning 5 mm distal to the stent, was measured before and after infusion of intracoronary acetylcholine (10(-7), 10(-6) mol/l) and then again after infusion of nitroglycerin. Blood pre...Continue Reading

References

Oct 5, 2001·Journal of the American College of Cardiology·A PrasadA A Quyyumi
Aug 29, 2003·The Journal of Biological Chemistry·Hui ChenMichael J Quon
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Feb 10, 2004·Biochemical and Biophysical Research Communications·Hiroyuki MotoshimaBarry J Goldstein
Jun 9, 2005·Hypertension·Ronald ClasenUlrich Kintscher
Jul 19, 2005·Journal of the American College of Cardiology·Mario TogniOtto M Hess
Dec 2, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi MorimotoKatsunori Sawada
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
May 3, 2008·Journal of the American College of Cardiology·Hirofumi YasueUNKNOWN SCAST (Statin and Coronary Artery Spasm Trial) Investigators
May 14, 2008·Expert Opinion on Pharmacotherapy·Teruo Inoue, Koichi Node
Feb 5, 2010·JACC. Cardiovascular Interventions·Lakshmana K PendyalaDongming Hou
Feb 12, 2011·Journal of the American College of Cardiology·Ailin BarseghianMandeep Bajaj
Mar 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomotaka DohiHiroyuki Daida

❮ Previous
Next ❯

Citations

Apr 11, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisato Takagi, Takuya Umemoto
Mar 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoji NeishiKiyoshi Yoshida
Mar 8, 2014·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Giampaolo NiccoliFilippo Crea
Sep 16, 2015·Current Hypertension Reports·Eugenia GkaliagkousiStella Douma
Dec 10, 2016·The Indian Journal of Medical Research·Miroslav RadenkovicMilica Prostran
Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.