Protective Effect of Thioctic Acid on Renal Ischemia-reperfusion Injury in Rat

International Journal of Preventive Medicine
Hassan Ahmadvand, Sina Mahdavifard

Abstract

We investigated the effect of thioctic acid (TA) on kidney function, oxidative stress, and inflammatory status in serum and kidney homogenates of a rat subjected to ischemia-reperfusion injury (IRI). Thirty male Wistar rats were randomly divided into three equal groups: sham, IR, and IR + TA in 50 mg/kg once-daily intraperitoneal injection for 2 weeks, before IR induction. The levels of urea and creatinine (Cr) in the serum of rats were measured. Malondialdehyde and nitric oxide (NO) as stress oxidative markers; tumor necrosis factor-α, interleukin-6, and myeloperoxidase as inflammatory markers, as well as activities of superoxide dismutase, glutathione peroxidase and catalase, and glutathione (GSH) level in both serum and kidney homogenates were determined. Cr and urea increased in serum of IR group. Furthermore, levels of oxidative stress and inflammatory markers in serum and kidney homogenates of the cited group were higher than the sham group. TA not only decreased the levels of Cr, urea, oxidative stress, and inflammation but also elevated the level of GSH and activities of antioxidant enzymes (P < 0.001). The findings showed that TA protected IR rat against kidney dysfunction and IRI due to reinforcing endogenous antioxid...Continue Reading

References

Nov 14, 2006·Respiratory Medicine·Kristina AndelidAnn Ekberg-Jansson
Oct 19, 2007·Clinical and Experimental Pharmacology & Physiology·Ozer SehirliGöksel Sener
Jul 6, 2012·Inflammation & Allergy Drug Targets·Andreas VossClaus Kerkhoff
Jan 13, 2015·Molecular Medicine Reports·Houliang DengAimin Ji
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Yogesh ScindiaSundararaman Swaminathan
Jul 15, 2015·Balkan Medical Journal·Ozan TuramanlarCevat Aktaş
Jan 30, 2016·Journal of the American Society of Nephrology : JASN·Lajos MarkóDominik N Müller
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lisha ZhaoJinyong Peng
Oct 27, 2011·Pharmaceuticals·Priscila Longhin BosquesiMan Chin Chung
Oct 17, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xuefei LiHong Jiang
Jan 18, 2018·Archives of Biochemistry and Biophysics·Yasuaki Aratani

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
MDA

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.