Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

Molecular Medicine Reports
Hui LiuNan Li

Abstract

Thymoquinone is the main active monomer extracted from black cumin and has anti‑inflammatory, antioxidant and anti‑apoptotic functions. However, the protective effects of thymoquinone on cardiovascular function in diabetes remain to be fully elucidated. The present study aimed to investigate the molecular mechanisms underling the beneficial effects of thymoquinone on the cardiovascular function in streptozotocin‑induced diabetes mellitus (DM) rats. Supplement thymoquinone may recover the insulin levels and body weight, inhibit blood glucose levels and reduce the heart rate in DM‑induced rats. The results indicated that the heart, liver and lung to body weight ratios, in addition to the blood pressure levels, were similar for each experimental group. Treatment with thymoquinone significantly reduced oxidative stress damage, inhibited the increased endothelial nitric oxide synthase protein expression and suppressed the elevation of cyclooxygenase‑2 levels in DM‑induced rats. In addition, thymoquinone significantly suppressed the promotion of tumor necrosis factor‑α and interleukin‑6 levels in the DM‑induced rats. Furthermore, administration of thymoquinone significantly reduced caspase‑3 activity and the promotion of phosphorylat...Continue Reading

References

Mar 15, 2006·Cardiovascular & Hematological Agents in Medicinal Chemistry·Alejandro de la Sierra
Nov 12, 2009·Life Sciences·Leelavinothan Pari, Chandrasekaran Sankaranarayanan
Jan 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·An HuangDong Sun
Apr 25, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Noureddine Idris-Khodja, Valérie Schini-Kerth
Jun 20, 2012·Current Molecular Medicine·S M CabreraR G Mirmira
Sep 7, 2013·Urologia Internationalis·Murat Mehmet RifaiogluNebiat K Sefil
Jan 15, 2014·International Journal of Biological Macromolecules·Masood A KhanHina Younus
Nov 5, 2014·General Physiology and Biophysics·Aymen Mabrouk, Hassen Ben Cheikh
Dec 3, 2014·International Journal of Surgery·İlker Öngüç AycanAbdulmenap Güzel
Feb 27, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Suguna PeriyanayagamVijaiyan Siva Ganesan
Mar 25, 2015·Journal of Diabetes Investigation·Kitty Kit Ting CheungJuliana Chung Ngor Chan
Dec 2, 2015·Experimental and Therapeutic Medicine·Jiming HanCailian Ruan

❮ Previous
Next ❯

Citations

Feb 22, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Tao DingHaiyan Hu
Jan 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phiwayinkosi V DludlaRabia Johnson
Dec 5, 2018·Oxidative Medicine and Cellular Longevity·Mustafa S AttaShaker A Mousa
Dec 27, 2017·Molecular Nutrition & Food Research·Merve BekerBirsen Elibol
Oct 31, 2017·Asian Pacific Journal of Tropical Medicine·Tahereh FarkhondehAbasalt Borji
Dec 15, 2020·Phytotherapy Research : PTR·Masoumeh FadisheiHossein Hosseinzadeh
Sep 10, 2019·Mitochondrion·T N GolevaR A Zvyagilskaya
Jan 21, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Barış AkgülMutay Aslan
Mar 21, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zeynab KohandelSaeed Samarghandian
May 4, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Asghar Ashrafi HafezAhmad Salimi
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tugce DalliBirsen Elibol

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis