Protective effect of thymoquinone in experimental testicular torsion

Urologia Internationalis
Ahmet GökçeMehmet Duru

Abstract

To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), torsion/detorsion (TD) and TD+TQ. Mice, except the sham-operated group, were subjected to left unilateral torsion (720° rotation in the clockwise direction). The experiments were finished after sham operation time for controls, 120 min torsion and 240 min detorsion for the other groups. In the TD+TQ group 10 mg TQ was injected intraperitoneally 30 min before detorsion. In the TD group total oxidative stress (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were higher than in the controls. TQ treatment decreased MDA, TOS and OSI values, but did not affect the total antioxidant capacity and myeloperoxidase activity in the TD+TQ group. Upon histological examination, mice in the TD group displayed moderate-to-severe disruption of the seminiferous epithelium. Treatment with TQ resulted in significantly reduced histological damage associated with I/R injury. Our results suggested that TQ treatment may have a protective effect on testicu...Continue Reading

Citations

Jun 18, 2014·Nature Reviews. Urology·Ersagun KaraguzelOmer Kutlu
Jun 5, 2015·Systems Biology in Reproductive Medicine·Nur Hande TüfekSüleyman Kaplan
Oct 16, 2015·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ufuk TasMustafa Sarsilmaz
Jul 3, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Caferi Tayyar SelçukMustafa Kemal Basarali
Apr 5, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Mehmet Ali KaragozArif Aydin
Apr 14, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehmet Hanifi OkurIbrahim Kaplan
Aug 10, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Duygu HerekFurkan Ufuk
Oct 20, 2019·Revista Internacional De Andrología·Fikret Altindağ, Murat Çetin Rağbetli
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Essmat M El-SherefElShimaa M N Abdelhafez

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