Protective effect of turmeric extract on ethotrexate-induced intestinal damage and oxidative stress

Chinese Journal of Natural Medicines
Adel Rezaei MoghadamMohammad Mazani

Abstract

The most important side effect of methotrexate (MTX) is mucositis. The purpose of this study was to evaluate the effect of turmeric extract on intestinal damage and oxidative stress in rats receiving methotrexate. Experiments were performed on male Wistar albino rats divided into six groups. First group received normal saline orally, the second group received turmeric extract (100 mg·kg(-1)) orally for 30 days, the third group received turmeric extract (200 mg·kg(-1)) orally for 30 days, the fourth group received a single dose of methotrexate (20 mg·kg(-1)) i.p. at day 30, the fifth group received turmeric extract (100 mg·kg(-1)) orally for 30 days and a single dose of methotrexate (20 mg·kg(-1)) i.p. at day 30, and the sixth group received turmeric extract (200 mg·kg(-1)) orally for 30 days and single dose of methotrexate (20 mg·kg(-1)) i.p. at day 30. Four days after methotrexate injection, animals were anesthetized, blood samples were taken to determine total antioxidant status (TAS) and jejunum samples were taken for glutathione peroxidase (GPx), superoxidase dismutase (SOD), catalase (CAT), aldehyde malondialdehyde (MDA), and histopathological assessment. Microscopic evaluation from intestinal tissues of the MTX treated gr...Continue Reading

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Jan 24, 2003·Expert Opinion on Therapeutic Targets·Elizabeth A HilemanPeng Huang
May 5, 2004·Cell Biochemistry and Function·Nermina JahovicBerrak C Yeğen

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Citations

Nov 3, 2016·Experimental Animals·Aynur ArslanHalis Suleyman
Mar 23, 2018·Critical Reviews in Food Science and Nutrition·Fernando Cunha NetoSandra Maria Barbalho

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