PMID: 19930886Nov 26, 2009Paper

Protective effect of ulinastatin on lung injury induced by simultaneous pancreas-kidney transplantation in piglet

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Yong-quan ChenXiao-peng Chen

Abstract

To evaluate the effects of ulinastatin (UTI) on lung injury induced by simultaneous pancreas-kidney transplantation in piglet. With reproduction of simultaneous pancreas-kidney transplantation model in piglets, 12 couples of piglets were randomly divided into two groups (n=12). Piglets in UTI group were given a constant infusion of UTI 15 kU x kg(-1) x h(-1) by means of a pump during operation. Control group were treated with constant pumped infusion of 0.9% saline in equal volume. The blood samples were collected to measure the plasma concentrations of superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) before operation (baseline levels, T0), at the time of re-establishment of circulation with successful an anastomosis of arteries and veins (T1), at 1 hour and 2 hours after re-establishment of circulation (T2 and T3), and at the end of operation (T4). The pathological changes in the lungs were examined. In control group, plasma MDA concentration was significantly increased from T1 till T4 as compared with T0 (all P<0.05), whereas in group UTI it did not change significantly (all P>0.05). In group UTI, SOD activity was significantly increased at T1-2 and T4 as comp...Continue Reading

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