Protective effect of unsymmetrical dichalcogenide, a novel antioxidant agent, in vitro and an in vivo model of brain oxidative damage

Chemico-biological Interactions
Marina PrigolCristina W Nogueira

Abstract

Unsymmetrical dichalcogenides, a class of organoselenium compounds, were screened for antioxidant activity in rat brain homogenates in vitro. Unsymmetrical dichalcogenides (1-3) were tested against lipid peroxidation induced by sodium nitroprusside (SNP) or malonate, and reactive species (RS) production induced by sodium azide in rat brain homogenates. Compounds 1 (without a substituent at the phenyl group), 2 (chloro substituent at the phenyl group bounded to the sulfur atom) and 3 (chloro substituent at the phenyl group bounded to the selenium atom) protected against lipid peroxidation induced by SNP. The IC50 values followed the order 3<2<1. Lipid peroxidation induced by malonate was also reduced by dichalcogenides 1, 2 and 3. The IC50 values were 3<or=2<1. RS production induced by sodium azide was reduced by compounds 1-3 (IC50 values were 3<2<or=1). Compounds 1-3 were screened against oxidatively modified protein in rat brain homogenates. Compound 3 presented the lowest value of IC50 23.5 microM (IC50 values were 3<2<or=1). Compounds 1-3 at 40 microM displayed thiol peroxidase-like activity in rat brain homogenates. Since compound 3 was the most efficient antioxidant against lipid and protein oxidation in rat brain homogen...Continue Reading

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