Protective effect of UW solution on postischemic injury in rat liver: suppression of reduction in hepatic antioxidants during reperfusion

Transplantation
K SumimotoK Dohi

Abstract

Preservation with University of Wisconsin (UW) solution can maintain liver graft function and produces survival rates of recipients higher than that with Euro Collins (EC) solution. To explore the underlying mechanisms, we transplanted rat livers following cold preservation with EC or UW solution for 18 hr, and measured hepatic adenine nucleotide levels, the percentage of water content, lactate levels, and endogenous antioxidant levels (alpha-tocopherol [alpha-Toc], reduced coenzyme Q9 [CoQ9H2], reduced coenzyme Q10, [CoQ1OH2] and reduced glutathione [GSH] during preservation and after transplantation. The adenosine triphosphate levels of the liver grafts preserved with UW solution recovered after reperfusion more rapidly and reached a higher level than those preserved with EC solution. UW solution caused a reduction in hepatic water content during preservation. Conversely, EC solution induced remarkable tissue edema. In addition, UW solution reduced the rate of hepatic lactate production both during preservation and after reperfusion. The concentrations of hepatic GSH, alpha-Toc, CoQ9H2, and CoQ1OH2 immediately after the graftectomy, and after the 18 hr of preservation with both EC and UW solutions, did not differ from those i...Continue Reading

References

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Citations

Sep 19, 2012·Journal of Bioenergetics and Biomembranes·F A García-GilJ J García
Dec 4, 2003·Bioelectrochemistry·M SchaeferM M Gebhard
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Kukan, P S Haddad
Jun 7, 2013·Free Radical Research·M Elias-MiróC Peralta
Dec 27, 2005·Journal of Vascular Surgery·Vikas Chander, Kanwaljit Chopra
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luigi AccatinoCecilia S Koenig
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leticia FernándezCarmen Peralta
Apr 16, 2005·World Journal of Gastroenterology : WJG·Ying ChengNing Zhao
Jun 26, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gerardo NardoneAntonio Colantuoni

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