Protective effect of zinc over lead toxicity on testes

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Muhammad RafiqueFazila Tahir

Abstract

To determine the effects of lead and zinc on testes. Randomized control trial. Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, from August 2003 to December 2005. Sixty adult (90 days old) albino rats were obtained from animal house JPMC for the study and divided into 3 groups. Group A received injection normal saline 1 cc intraperitoneally daily for 8 weeks. Group B received lead chloride in a dose of 10 mg/kg body weight intraperitoneally daily. Group C received zinc chloride in a dose of 1 mg/kg body weight before half an hour of injection of lead chloride in a dose of 10 mg/kg body weight intraperitoneally daily so that to provide pre-treatment. On the day of completion of treatment the animals were sacrificed testes removed and fixed in Bouin's fluid. Testes were dehydrated in the ascending strength of alcohol, 5 mum thick sections were cut and stained with PAS Iron Hematoxylin. Student's t-test was used for statistical analysis with significance at p < 0.05. The mean diameter of seminiferous tubule was 291.91 + or - 1.18, 198.53 + or - 1.67 and 288.77 + or - 1.11 microm in groups A, B and C respectively. Diameter of seminiferous tubules decreased by 31.99% in group B (p < 0.001; CI 89.023 to ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Postgraduate Medical Journal
A W Spence
Lancet
Saurabh KumarRobert D Abraham
Journal of Assisted Reproduction and Genetics
Majedah Al-AzemiAlexander E Omu
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Yunping HuYunfei Wang
The Indian Journal of Medical Research
S GargR J Dash
© 2021 Meta ULC. All rights reserved