Protective Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O -β-d-glucoside on Ovariectomy Induced Osteoporosis Mouse Model

International Journal of Molecular Sciences
Su-Jin KimSung-Tae Yee

Abstract

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active polyphenolic component of Polygonum multiflorum, exhibits many pharmacological activities including antioxidant, anti-inflammation, and anti-aging effects. A previous study demonstrated that TSG protected MC3T3-E1 cells from hydrogen peroxide (H₂O₂) induced cell damage and the inhibition of osteoblastic differentiation. However, no studies have investigated the prevention of ovariectomy-induced bone loss in mice. Therefore, we investigated the effects of TSG on bone loss in ovariectomized mice (OVX). Treatment with TSG (1 and 3 μg/g; i.p.) for six weeks positively affected body weight, uterine weight, organ weight, bone length, and weight change because of estrogen deficiency. The levels of the serum biochemical markers of calcium (Ca), inorganic phosphorus (IP), alkaline phosphatase (ALP), and total cholesterol (TCHO) decreased in the TSG-treated mice when compared with the OVX mice. Additionally, the serum bone alkaline phosphatase (BALP) levels in the TSG-treated OVX mice were significantly increased compared with the OVX mice, while the tartrate-resistant acid phosphatase (TRAP) activity was significantly reduced. Furthermore, the OVX mice treated with TSG sho...Continue Reading

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Citations

Dec 14, 2018·International Journal of Molecular Sciences·Yun-Ho HwangSung-Tae Yee
Apr 26, 2021·Trends in Endocrinology and Metabolism : TEM·Daniele BellaviaGianluca Giavaresi
Jul 27, 2021·Experimental Biology and Medicine·Ying ZhouYang Wang

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Methods Mentioned

BETA
hormone replacement therapies
hormone replacement therapy
enzyme-linked immunoassay
ELISA

Software Mentioned

CTAn ( CT - Analyser )
SPSS
NRecon
CTvol
image J

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