Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation

European Journal of Pharmacology
Salvatore CuzzocreaC Szabó

Abstract

A cytotoxic cycle triggered by oxidant-induced DNA single strand breakage and subsequent activation of the nuclear enzyme poly (ADP-ribose) synthetase have been shown to contribute to the cellular injury during various forms of oxidant stress in vitro. The aim of the present study was to investigate the role of poly (ADP-ribose) synthetase in a model of acute local inflammation (carrageenan-induced pleurisy), where oxyradicals, nitric oxide and peroxynitrite are known to play a crucial role in the inflammatory process. The results show that the poly (ADP-ribose) synthetase inhibitor 3-aminobenzamide (given at 1-30 mg/kg) inhibits the inflammatory response (pleural exudate formation, mononuclear cell infiltration, histological injury). Moreover, 3-aminobenzamide reduces the formation of nitrotyrosine, an indicator of the formation of peroxynitrite, in the lung. The present results demonstrate that 3-aminobenzamide, presumably by inhibition of poly (ADP-ribose) synthetase, exerts potent anti-inflammatory effects. Part of the anti-inflammatory effects of 3-aminobenzamide may be related to a reduction of neutrophil recruitment into the inflammatory site.

References

Jan 1, 1991·Molecular Aspects of Medicine·C G Cochrane
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·C SzabóJ R Vane
Jan 1, 1994·The Biochemical Journal·C Pellat-DeceunynckJ C Drapier
Nov 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·R M Clancy, S B Abramson
Mar 1, 1995·Intensive Care Medicine·S Fujishima, N Aikawa
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
May 15, 1996·European Journal of Pharmacology·D SalveminiP T Manning
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ThiemermannJ R Vane
Apr 17, 1997·Biochemical and Biophysical Research Communications·M LeistP Nicotera

❮ Previous
Next ❯

Citations

Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
Sep 30, 2000·European Journal of Pharmacology·S CuzzocreaC Thiemermann
Aug 30, 2001·European Journal of Pharmacology·S Cuzzocrea, R J Reiter
Jul 31, 1998·European Journal of Pharmacology·C Szabó
Mar 10, 2000·European Journal of Pharmacology·S CuzzocreaC Thiemermann
Apr 20, 2000·Neuroscience·T LiuD J Tracey
Feb 22, 2001·British Journal of Pharmacology·D SalveminiS Cuzzocrea
Jan 30, 2002·British Journal of Pharmacology·Salvatore CuzzocreaChristoph Thiemermann
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·S CuzzocreaA P Caputi
Mar 2, 2006·Journal of Neurosurgery. Spine·Tiziana GenoveseSalvatore Cuzzocrea
Jun 1, 2013·International Journal of Molecular Medicine·Katalin ErdélyiCsaba Szabó
Jan 22, 2014·International Immunopharmacology·Sheikh Fayaz AhmadSaleh A Bakheet
Mar 22, 2007·European Journal of Pharmacology·Susana Sánchez-FidalgoCatalina Alarcón de la Lastra
Jul 15, 2011·Journal of Pineal Research·Virginia MotilvaMatilde Illanes
Oct 3, 2003·British Journal of Pharmacology·Carolina MuscoliDaniela Salvemini
Mar 8, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Oguz KokselIsmail Cinel
May 25, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Salvatore Cuzzocrea
Mar 8, 2006·Free Radical Biology & Medicine·Marta MenegazziSalvatore Cuzzocrea
Oct 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danae Carrillo-OcampoVerónica Rodríguez-López
Jun 6, 2006·Medicinal Research Reviews·Ana OlmosSalvador Máñez
Mar 8, 2005·Arthritis and Rheumatism·Salvatore CuzzocreaChristoph Thiemermann
Jul 18, 2002·Nature Reviews. Drug Discovery·Daniela SalveminiSalvatore Cuzzocrea
Aug 30, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ruben A MotaJosé Yélamos
Jan 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tiziana GenoveseSalvatore Cuzzocrea
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S CuzzocreaA P Caputi
May 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roberta FuscoSalvatore Cuzzocrea
May 23, 2000·Journal of Neurochemistry·S DucrocqC Charriaut-Marlangue
Jan 25, 2003·Critical Care Medicine·Daniela Salvemini, Salvatore Cuzzocrea
May 3, 2003·Intensive Care Medicine·Marion ScharteHans-Georg Bone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here