Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42 -Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice

International Journal of Molecular Sciences
Fabiana MorroniPatrizia Hrelia

Abstract

Alzheimer's disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in Wasabia japonica, which is a typical Japanese pungent spice. Recently, in vivo and in vitro studies demonstrated that 6-MSITC has several biological properties. The aim of the present study was to investigate the neuroprotective activity of 6-MSITC in a murine AD model, induced by intracerebroventricular injection of β-amyloid oligomers (Aβ1-42O). The treatment with 6-MSITC started 1 h after the surgery for the next 10 days. Behavioral analysis showed that 6-MSITC ameliorated Aβ1-42O-induced memory impairments. The decrease of glutathione levels and increase of reactive oxygen species in hippocampal tissues following Aβ1-42O injection were reduced by 6-MSITC. Moreover, activation of caspases, increase of inflammatory factors, and phosphorylation of ERK and GSK3 were inhibited by 6-MSITC. These results highlighted an interesting neuroprotective activity of 6-MSITC, which was able to restore a physiological oxidative status, interfere positively with Nrf2...Continue Reading

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Citations

Jan 15, 2020·Molecular and Cellular Biology·Akira UrunoMasayuki Yamamoto
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Patrizia HreliaSilvana Hrelia
Sep 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji Hyun KimEun Ju Cho
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sajad FakhriEduardo Sobarzo-Sánchez

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Methods Mentioned

BETA
transgenic
ubiquitination
ELISA
PCR

Software Mentioned

AxioVision
GraphPad
PRISM
Quantity One
EthoVision
AxioVision Rel
ImageJ

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