Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva

Journal of Clinical Biochemistry and Nutrition
Yusaku TanakaNobushiro Hamada

Abstract

We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with a laser Doppler probe. RH increased in a time-dependent manner when the duration of compression was between 30 s and 20 min. This increase was significantly suppressed by N (ω)-nitro-l-arginine-methyl-ester (l-NAME), 7-nitroindazole (7-NI), and 2,4-diamino-6-hydroxypyrimidine (DAHP). However, RH was markedly inhibited following 60 min of compression. This inhibition was significantly decreased by treatments with superoxide dismutase (SOD), (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4), and sepiapterin. The luminescent intensity of superoxide anion (O2 (•-))-induced 2-methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo-[1,2-a] pyrazine-3-one (MCLA) was markedly decreased by SOD and BH4, but only slightly by sepiapterin. BH4 significantly decreased O2 (•-) scavenging activity in a time-dependent manner. These results suggested that nitric oxide (NO) secreted by the nitrergic nerve played a role in regulating local circulation in rat gingiva. This NO-related regulati...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Jan 1, 1990·Journal of Clinical Gastroenterology·T YoshikawaM Kondo
May 1, 1989·The Journal of Surgical Research·J A GalatR S Rhodes
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Jan 1, 1985·Annual Review of Biochemistry·C A NicholD S Duch
Oct 1, 1986·The American Journal of Physiology·M B GrishamD N Granger
Dec 1, 1988·The American Journal of Physiology·D N Granger
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Oct 1, 1974·Circulation Research·R J BacheJ C Greenfield
Jan 1, 1993·Journal of Cardiovascular Pharmacology·R F Furchgott
Jun 1, 1995·Annals of Medicine·I Paakkari, P Lindsberg
Apr 1, 1996·The American Journal of Physiology·I T MeredithM A Creager
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·H W LiuR Kradin
Aug 28, 1998·European Journal of Pharmacology·B BrüneK B Sandau
Apr 1, 2000·Plastic and Reconstructive Surgery·B M SundinB Klitzman
Oct 21, 2000·FEBS Letters·J Vásquez-Vivar, B Kalyanaraman
Oct 6, 2001·Nitric Oxide : Biology and Chemistry·J M SchoenW W Lautt
Dec 12, 2001·American Journal of Physiology. Renal Physiology·José G Van Den BergJan J Weening
Jul 3, 2002·Molecular and Cellular Neurosciences·Michael HenrichWolfgang Kummer
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Pablo A Ortiz, Jeffrey L Garvin
Apr 12, 2003·Redox Report : Communications in Free Radical Research·Yoichi OmoriKazuo Todoki
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Oct 1, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryotaro BouchiYasuhiko Iwamoto
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Shuta SugiyamaMasaichi-Chang-Il Lee
Feb 11, 2015·International Journal of Food Sciences and Nutrition·Ryuji OchiaiTeruto Hashiguchi
Feb 13, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohisa NezuMasayasu Matsumoto
Mar 12, 2015·Journal of Clinical Biochemistry and Nutrition·Shigeru ShimadaMasaichi-Chang-Il Lee

❮ Previous
Next ❯

Citations

Sep 7, 2019·Clinical Advances in Periodontics·Grigoris Thermos, Konstantinos I Tosios
Feb 13, 2020·Journal of Applied Oral Science : Revista FOB·Masahiro ToShun-Suke Takahashi
Mar 23, 2021·Journal of Oral Biosciences·Reiko YamamotoMasato Matsuo

❮ Previous
Next ❯

Software Mentioned

AQUACOSMOS
Chart

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.