Protective effects of acute lithium preconditioning against renal ischemia/reperfusion injury in rat: role of nitric oxide and cyclooxygenase systems

European Journal of Pharmacology
Saman Shafaat TalabAhmad Reza Dehpour

Abstract

Delayed graft function secondary to ischemia/reperfusion injury has been shown to be associated with increased rate of allograft failure following kidney transplantation. Previously, we have shown that chronic lithium pretreatment protects kidney against ischemia/reperfusion injury. In the present study we aimed to examine the effects of acute lithium administration on the renal ischemia/reperfusion injury in rat. Ischemia/reperfusion injury was induced by clamping left renal pedicle for 60 min, two weeks after right nephrectomy. The mechanism of lithium-mediated renoprotection was explored by combined use of lithium and nitro-l-arginine methyl ester (L-NAME) (non-selective nitric oxide synthase inhibitor) and/or indomethacin (non-selective cyclooxygenase pathway inhibitor). Lithium-treated animals were given 40 mg/kg lithium chloride intraperitoneally, 30 min before ischemia. To investigate the role of nitric oxide and cyclooxygenase pathways in renoprotective effect of lithium, L-NAME and/or indomethacin were administered before lithium injection. Serum creatinine, blood urea nitrogen, and renal histology were assessed after 24h of reperfusion. Lithium preconditioning significantly reduced creatinine and blood urea nitrogen (...Continue Reading

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Citations

Feb 8, 2013·Journal of Endourology·Ramazan AltintasHakan Parlakpinar
Nov 14, 2012·Kidney & Blood Pressure Research·Ramazan AltintasGul Pelin Odabas
Feb 16, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bert BoscheFrauke V Härtel
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Jul 26, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Merhan Mamdouh Ragy, Neven Makram Aziz
Jan 11, 2014·Journal of the American Society of Nephrology : JASN·Man J Livingston, Zheng Dong
Sep 25, 2020·International Journal of Molecular Sciences·Hee-Yeon JungJang-Hee Cho
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elizabeth O DanganaLawrence A Olatunji
May 8, 2014·ACS Chemical Neuroscience·Ahmad Nassar, Abed N Azab

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