Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats

Planta medica
Luzia Kalyne Almeida Moreira LealG S Viana

Abstract

The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl)benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. AMB is a phenol glucoside from the Brazilian medicinal plant Amburana cearensis, popularly used for the treatment of respiratory tract affections. Acute AMB (25 and 50 mg/kg, I. P. or P. O.) treatments of CCl (4)-intoxicated rats significantly inhibited the increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as compared to the group treated with CCl (4) only. Histological studies showed less centrolobular necrosis and inflammatory cell infiltrates in the liver of animals treated with AMB plus CCl (4), when compared to the group treated with CCl (4) alone. In hepatic tissues, AMB at both doses inhibited CCl (4)-induced thiobarbituric acid-reactive substances (TBARS) formation, indicating a blockade of CCl (4)-induced lipid peroxidation. AMB also reversed the decrement in glutathione contents of hepatic tissues in CCl (4)-intoxicated rats. Furthermore, it restored catalase activity to normal values, which was significantly increased after CCl (4) treatment. Our results indicate that CCl ...Continue Reading

Citations

Jul 23, 2011·Anais Da Academia Brasileira De Ciências·Paulo Michel P FerreiraAna F U Carvalho
Jul 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliana Helena Castro E SilvaSilvia Lima Costa
Dec 4, 2020·3 Biotech·Maria Tatiana Alves OliveiraAdriana Ferreira Uchoa
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L K A M LealG S B Viana

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