PMID: 8580698Aug 1, 1995Paper

Protective effects of Angelica sinensis injection on myocardial ischemia/reperfusion injury in rabbits

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
S G ChenX X Zhuang

Abstract

The injection of aqueous extract of Angelica sinensis (AS), 50 mg/kg, 30 ml, were administered intravenously at a rate of 0.4 ml/min by an infusion pump 10 min before the left anterior descending coronary artery of rabbit was ligated, the LVP and +/- dp/dtmax of the rabbit heart injured by ischemia/reperfusion in vivo, were significantly higher than those in the control group (N.S. group, P < 0.05-0.01), and the level of malon-dialdehyde (MDA) and the activity of creatine phosphokinase (CPK) in the blood plasma were lower than those in the control group remarkably (P < 0.05-0.01). These results showed that AS exerted obvious protective effects on myocardial dysfunction and myocardial injury induced by ischemia/reperfusion.

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